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'Rules of Life' outlines path to predicting phenotype（图）
Rules of Life outlines path predicting phenotype
2017/9/4
Imagine a world where scientists can predict with confidence whether crops will grow in extreme temperatures, just by understanding their genetic makeup. Consider a future where doctors can know what ...
Cholecystokinin responsiveness varies across the population dependent on metabolic phenotype
cholecystokinin obesity drug development hormonal responsiveness population study cholesterol epidemiology
2018/11/15
Background: Cholecystokinin (CCK) is an important satiety factor, acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clinical trials for obesity. We postu...
Protein- and zinc-deficient diets modulate the murine microbiome and metabolic phenotype
malnutrition metabolome metabolic phenotype metabolome metabonomics microbiome microbiota, protein deficiency undernutrition
2018/12/18
Background: Environmental enteropathy, which is linked to undernutrition and chronic infections, affects the physical and mental growth of children in developing areas worldwide. Key to understanding ...
Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial
CVD risk isoflavone flavonoids vascular function equol producer phenotype arterial stiffness
2018/11/28
Background: There is much speculation with regard to the potential cardioprotective benefits of equol, a microbial-derived metabolite of the isoflavone daidzein, which is produced in the large intesti...
Lymph node and peri-lymph node stroma : phenotype and interaction with T-cells
Ly51 iNOS IDO1
2015/5/21
The non-hematopoietic, stationary stromal cells located inside and surrounding skin-draining lymph nodes play a key role in regulating immune responses. We studied distinct populations of lymph node s...
Evidence of an Infectious Asthma Phenotype: Chlamydia Driven Allergy and Airway Hyperresponsiveness in Pediatric Asthma
allergy asthma atopy chlamydia hyperresponsivness
2015/1/28
Asthma is the most common chronic respiratory disease affecting young children and adults all over the world. An estimated 34.1 million Americans have reported asthma in their lifetime and the disease...
TRAF-interacting protein, an inhibitor of the canonical nuclear factor-kappaB pathway, plays a key role in the estradiol -dependent apoptosis of the dual-phenotype gamma amino butyric acid/glutamate neurons in the anteroventral periventricular nucleus of the male rat
Mediated estradiol LH surge neurons male AVPV E2 - mediated cell death neurons
2014/12/11
The anteroventral periventricular nucleus (AVPV) of the preoptic area mediates the positive feedback effects of estradiol (E2) on LH surge in rats. Consistent with their role in female reproduction, t...
Regulation and Action of Skp2 and Rhoa in Cell and Tumor Models: Investigation into the Molecular Mechanisms Responsible for the Aggressive Phenotype of Triplenegative Breast Cancer
Basal-Like Breast Cancer Cell Cycle p27 proliferation SKP2 Triple-Negative Breast Cancer
2014/12/10
Breast cancer tops the list of new cancer cases and is predicted to be the second leading cause of cancer deaths in women in 2012. The primary objective of the present study was to provide insights in...
期刊信息
篇名
“A novel mutation at the jk locus causing JKnull phenotype in a chinese family”,
语种
英文
撰写或编译
撰写
作者
孟艳,周雪艳,李扬,赵丹,梁淑媛,赵雪俭*,杨宝学*
第一作者单位
吉林大学基础医学院病理生理学教研室
刊物名称
Science in China Series C: Life Scie...
期刊信息
篇名
nm23-H1 transfection can regulate the expression of downstream genes related to “Lung Cancer metastasis Suppress casecade” and reverse the metastatic phenotype of human high metastasis large c...
Fleece Phenotype Influences Susceptibility to Cortisol-induced Follicle Shutdown in Merino Sheep
Merino Strongwool Finewool Cortisol Injection Follicle Shutdown
2016/4/26
This experiment was conducted to determine the extent to which susceptibility to cortisol-induced follicle shutdown is influenced by fleece phentotype. Twenty Finewool (10 sheep low fibre diameter, lo...