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SARS-CoV-2是人类呼吸道冠状病毒之一，具有高度传播性，其感染会引发机体天然免疫反应，导致肺炎和急性呼吸窘迫综合征。然而，越来越多的COVID-19患者表现出肝脏、心脏、肾脏、血管系统，甚至是神经系统的损伤和严重的康复后遗症，系统研究SARS-CoV-2感染后机体各器官的全转录组变化对于认识宿主免疫应答机制十分必要。
李晓江团队在Protein Cell发表疾病大动物模型研究综述（图）
动物模型 神经 暨南大学 帕金森病
2024/3/26
神经退行性疾病（阿尔兹海默症、亨廷顿舞蹈症、帕金森病、肌萎缩侧索硬化症等）为何出现特定脑区的典型神经细胞死亡是神经科学领域一直关注的重点。小动物模型如最常用的小鼠模型因与人类大脑结构差异巨大，绝大多数无法模拟神经退行性病人典型神经细胞死亡的病理特征，且在小鼠脑疾病中发挥作用的药物在临床实验中多以失败而告终。2022年3月25日，来自暨南大学粤港澳中枢神经再生研究院的李晓江教授团队在Protein ...
Molecular characterization and expression pattern of a novel Keratin-associated protein 11.1 gene in the Liaoning cashmere goat (Capra hircus)
Liaoning Cashmere Goat Keratin-associated Protein 11.1 (KAP11.1) Expression Pattern
2017/3/9
An experiment was conducted to determine the relationship between the KAP11.1 and the regulation wool fineness.
Random Regression Models Using Legendre Polynomials to Estimate Genetic Parameters for Test-day Milk Protein Yields in Iranian Holstein Dairy Cattle
Holstein Dairy Cattle Milk Protein Yields Random Regression Model Test-day Records
2016/12/28
The objective of this study was to estimate the genetic parameters of milk protein yields in Iranian Holstein dairy cattle. A total of 1,112,082 test-day milk protein yield records of 167,269 first la...
Tudor Domain Containing Protein TDRD12 Expresses at the Acrosome of Spermatids in Mouse Testis
Tdrd12 Tudor Spermatogenesis Acrosome Spermatid Testis
2016/7/27
Tdrd12 is one of tudor domain containing (Tdrd) family members. However, the expression pattern of Tdrd12 has not been well studied. To compare the expression levels of Tdrd12 in various tissues, real...
The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase–Protein Kinase B–Mammalian Target of Rapamycin Signaling Pathway
Transepithelial Electrical Resistance Phosphatidylinositol 3-Kinase-Akt-mTOR Signaling Pathway
2016/5/20
Glucagon-like peptide-2 (GLP-2) is important for intestinal barrier function and regulation of tight junction (TJ) proteins, but the intracellular mechanisms of action remain undefined. The purpose of...
Heat Shock Protein Augmentation of Angelica gigas Nakai Root Hot Water Extract on Adipogenic Differentiation in Murine 3T3-L1 Preadipocytes
Angelica gigas Nakai Heat Shock Heat Shock Protein 3T3-L1 Adipogenesis
2016/5/19
There is a high association of heat shock on the alteration of energy and lipid metabolism. The alterations associated with thermal stress are composed of gene expression changes and adaptation throug...
Rumen Degradability and Small Intestinal Digestibility of the Amino Acids in Four Protein Supplements
Amino Acid Protein Small Intestinal Digestibility Rumen Degradability Absorbable Amino Acids
2016/5/19
The supplementation of livestock feed with animal protein is a present cause for public concern, and plant protein shortages have become increasingly prominent in China. This conflict may be resolved ...
Variance Components and Genetic Parameters Estimated for Fat and Protein Content in Individual Months of Lactation: The Case of Tsigai Sheep
Sheep Milk Composition Test Day Model Variance Ratios Heritability Genetic Correlations
2016/5/19
The objective of this study was to assess variance components and genetic parameters for fat and protein content in Tsigai sheep using multivariate animal models in which fat and protein content in in...
Mapping, Tissue Distribution and Polymorphism of Porcine Retinol Binding Protein Genes (RBP5 and RBP7)
Retinol Binding Protein Complete Coding Sequence Porcine Reverse Transcriptase Polymerase Chain Reaction Single Nucleotide Polymorphism Genotype
2016/4/28
The retinoids (vitamin A and its derivatives) play a critical role in vision, growth, reproduction, cell differentiation and embryonic development. Using the IMpRH panel, porcine cellular retinol bind...
Polymorphism of Insulin-like Growth Factor Binding Protein-4 Gene in 17 Pig Breeds and Its Relationship with Growth Traits
IGFBP-4 Gene Performance Traits Swine PCR-SSCP
2016/4/26
Insulin-like growth factor binding protein-4 (IGFBP-4) is a member of the IGF super family, and regulates the action of IGFs. The polymorphism of porcine IGFBP-4 gene in 17 pig breeds (total n = 570) ...
Molecular Cloning, mRNA Expression,and Localization of the G-protein Subunit Galphaq in Sheep Testis and Epididymis
Epididymis G-protein Subunit Galphaq [GNAQ] Sheep Testis
2016/12/28
The reproductive function of G-protein subunit Galphaq (GNAQ), a member of the G protein alpha subunit family, has been extensively studied in humans and rats. However, no data is available on its sta...
Role of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 in Ovarian Function and Their Importance in Mammalian Female Fertility — A Review
Cumulus Cells Granulosa Cells Oocyte Maturation Follicular Development Reproductive Efficiency TGF-β Superfamily
2016/11/10
Growth factors play an important role during early ovarian development and folliculogenesis, since they regulate the migration of germ cells to the gonadal ridge. They also act on follicle recruitment...
Factors affecting ewe’s milk fat and protein content and relationships between milk yield and milk components
sheep milk composition environmental effects correlations lactation curves
2015/6/4
Test-day records of purebred Tsigai, Improved Valachian and Lacaune ewes were used to analyse the effect of environmental factors on milk fat and protein content. There were 121 424 and 121 158 measur...
Effects of protein kinase C on parthenogenetic activation of pig oocytes using calcium ionophore or nitric oxide-donor
oocyte pig parthenogenesis activation calcium ionophore nitric oxide
2015/6/4
Porcine oocytes matured in vitro were activated for parthenogenetic development using either calcium ionophore (50μM for 10 min) or nitric oxide donor SNAP (2mM for 23.5 hours). Protein kinase C (PKC)...