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Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
SARS-CoV-2 human ACE2 transgenic mouse COVID-19 pneumonia
2020/6/11
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angi...
Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids
fat malabsorption fat balance lipolysis
2016/5/27
Pancreatic enzyme replacement therapy frequently
fails to correct intestinal fat malabsorption completely in
cystic fibrosis (CF) patients. The reason for this failure is
unknown.
Combination of Angiotensin Converting Enzyme Insertion/Deletion (I/D) (rs4646994) and VEGF Polymorphism (+405G/C; rs2010963) Synergistically Associated With the Development, of Albuminuria in Iranian Patients With Type 2 Diabetes
Vascular Endothelial Growth Factor Albuminuria Diabetes Mellitus Genetic Polymorphism
2015/10/20
Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and vascular endothelial growth factor (VEGF) polymorphisms have been shown to associate with diabetic nephropathy (DN).
A Study on Proteolytic Enzyme Activity in the Erythrocytes of Diabetic Patients
Oxidative stress Proteolytic activity Diabetes mellitus
2015/7/21
The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte l...
Viral Hepatitis And Enzyme Study
Jaundice enzyme assay correlation hepatocellular damage cholestasis
2015/7/21
The present study was undertaken in sixty patients of viral hepatitis of both sexes ranging 20 to 60 yrs. of age to compare serum levels or 5’Nucleotidase, Alkaline phosphatase, aspartate aminotransfe...
Cholecystitis & An Enzyme Study
Liver function enzyme markers clinical evaluation gall bladder.
2015/7/14
Cholecystitis is inflammation of the gallbladder that develops in short time usually when gallstone obstructs the cystic duct. Patients over the passage of time land to chronic cholecystitis. They hav...
Regulation of SRF Activity by the ATP-dependent Chromatin Remodeling Enzyme, CHD8
chromatin remodeling SRF apoptosis
2015/5/22
Under normal conditions, smooth muscle cells do not replicate, or proliferate, and provide a means of contraction for many internal organs, including blood vessels and the gut. However, under abnormal...
Association of Cardiorespiratory Fitness with Elevated Hepatic Enzyme and Liver Fat in Japanese Patients with Impaired Glucose Tolerance and Type 2 Diabetes Mellitus
Cardiorespiratory fitness hepatic enzyme non-alcoholic fatty liver abdominal obesity insulin resistance
2015/5/5
No study has so far determined whether a favorable level of cardiorespiratory fitness (CF) contributes to a reduced risk of elevated hepatic enzymes and a high degree of liver fat in patients having v...
Enhanced mtDNA repair and cellular survival following oxidative stress by targeting the hOGG repair enzyme to mitochondria
DNA repair DNA damage
2014/12/12
Oxidative damage to mtDNA has been implicated as a causative factor in many disease processes and in aging. We have recently discovered that different cell types vary in their capacity to repair this ...
Conditional Targeting of the DNA Repair Enzyme hOGG1 into Mitochondria
DNA repair mitochondria
2014/12/12
Oxidative damage to mitochondrial DNA (mtDNA) has been suggested to be a key factor in the etiologies of many diseases and in the normal process of aging. Although the presence of a repair system to r...
APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has a pleiotropic role in control...
FcγR-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
NADPH oxidase p40phox
2014/12/12
The phagocyte NADPH oxidase generates superoxide for microbial killing, and includes a membrane-bound flavocytochrome b558 and cytosolic p67phox, p47phox, and p40phox subunits that undergo membrane tr...
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
The c-MYC oncoprotein NAMPT enzyme SIRT1-inhibitor DBC1 SIRT1 deacetylase
2012/2/1
Silent information regulator 1 (SIRT1) represents an NAD+-dependent deacetylase that inhibits proapoptotic factors including p53. Here we determined whether SIRT1 is downstream of the prototypic c-MYC...
Effects of alendronate and risedronate therapy on hepatic antioxidant enzyme activity and lipid peroxidation in ovariectomized rats
Alendronate risedronate ovariectomy antioxidants
2010/10/14
To evaluate the effects of alendronate (ALN) and risedronate (RIS), which are agents for preventing and treating postmenopausal osteoporosis, on hepatic antioxidant enzyme activity and lipid peroxidat...
STUDY OF CORRELATION BETWEEN SYSTOLIC BLOOD PRESSURE AND ANGIOTENSIN CONVERTING ENZYME (ACE) ACTIVITY IN STZ INDUCED DIABETIC RATS
STZ induced diabetic rats Diabetes mellitus morbidity mortality
2010/1/6
Background: Diabetes mellitus is a worldwide health problem affecting 1-2% of the population. It is responsible for numerous morbidity and mortality consequences due to vascular events such as hyperte...