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The modification of the development of the high pressure nervous syndrome (HPNS) has been demonstrated by varying the external environment (chamber temperature, compression rate) or the internal envir...
Electroencephalographic activity of the frontal cortex, cerebellar vermis, and superior vestibular nucleus was recorded in awake rats during the high pressure nervous syndrome (HPNS) by means of perma...
Previous studies have demonstrated two tremorgenic systems that involve separate brain mechanisms and exhibit different peak frequencies. One system (the thalamo-cortical) generates low frequency (4--...
This study compares the effects of various so-called trimix mixtures (10, 20, and 40 percent N2 in He-O2) on the convulsion threshold pressure (Pc) and EEG activity in 60 adult male Wistar rats with c...
HPNS during rapid compressions of men breathing He-O2 and He-N2-O2 at 300 m and 180 m.
The effect of either 10, 8, or 6 meq/kg of intraperitoneal lithium chloride or sodium chloride on the loss of righting response (RR50) produced by 18.2 ATA N2-ATA O2 was examined in rats. Results were...
In 1978 a series of deep trimix (He-N2-O2) dives was initiated to establish the relationship between a given nitrogen percentage and the rate of compression required to prevent the high pressure nervo...
Previous man dives, in a series designed to evaluate the physiological effects of helium, nitrogen, and oxygen (trimix), investigated the comparative effects of 5 percent vs. 10 percent nitrogen with ...
The effect of change in injection pattern in nitrogen on threshold pressures of three symptoms associated with compression in helium/nitrogen atmospheres was explored. Excitement threshold pressures d...
Divers show symptoms of a condition known as the high pressure nervous syndrome (HPNS) at depths greater than about 180 m. A symptom that possibly lends itself to an objective diagnosis is a change in...
A series of benzazole-related, centrally acting muscle relaxants, comprising benzimidazole, chlorzoxazone, and zoxazolamine, were found to give substantial protection against the tremors and convulsio...
A H2-He-O2 mixture with 54 to 56% hydrogen was studied with 6 subjects (professional divers) during 2 dives to 450 m. The 38-h compression was the same as that used with other types of breathing mixtu...
Heliox compression deeper than 16 ATA can lead to EEG changes associated with confusion and somnolence. In man the symptoms termed the high pressure neurologic syndrome (HPNS) can also include increas...
A new baboon model was used to investigate the therapuetic effect of sodium valproate on the high pressure neurologic syndrome (HPNS). A hyperbaric chamber was used to achieve environmental pressures ...
The effects of two i.v. anesthetics, Saffan and methohexitone (MHX) and two N-methyl-D-aspartate receptor antagonists, MK-801 (Dizocilpine) and 2-aminophosphonoheptanoate (AP7), were tested for activi...

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