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NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
ALS MPTP SOD1 neurodegeneration
2015/5/21
The main, underlying cause of neurodegenerative disease is the progressive loss of neuronal structure or function, whereby central and/or peripheral nervous system circuitry is severely and irreversib...
Prenatal and Postnatal Exposures to 1-Methyl-4-phenyl-1,2,3,6-tetra Hydropyridine (MPTP) Impaired Mouse Midbrain Dopamine System and May Produce a Predisposing and Inducing Model for Parkinson’s Disease
Parkinson’s Disease Midbrain -Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)
2013/1/29
Dopamine cell bodies in the substantia nigra of the midbrain and with their terminals projecting to the neostriatum form the nigrostriatum and these dopamine neurons degenerate in Parkinson’s disease ...
锰卟啉络合物对MPTP诱导的帕金森病小鼠的防治作用
帕金森病 MPTP 锰卟啉络合物 氧化应激
2008/5/14
目的：观察锰卟啉络合物\[manganese(Ⅲ) meso-tetrakis(N,N′-diethylimidazolium-2-yl) porphyrin,MnTDM\]对1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine，MPTP)诱导的早期帕金森病模型小鼠的防治效果，探讨其可能的作用机制。方...
灵芝孢子油对MPTP处理小鼠行为学及黑质区病理变化的影响
2007/7/25
人类帕金森病(PD)是一种在遗传易感性基础上加环境因素共同作用下导致的神经系统慢性退行性疾病，主要病理改变是中脑黑质致密部(substantia nigra pars compacta，SNpc)多巴胺(dopamine，DA)能神经元进行性减少，引起黑质纹状体通路上DA水平降低[1]。预防和治疗PD的策略是干预和终止发病机制中的关键环节。只有采取有效措施预防黑质多巴胺能神经元进行性死亡，才能避免...