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The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma
Asthma Bronchoconstriction Fish Oil
2015/5/22
Asthma, a chronic inflammatory disease of the airways, affects nearly 25 million Americans. The vast majority of these patients suffer from exercise-induced bronchoconstriction (EIB), a complication o...
Involvement of Fibronectin and Matrix Metalloproteinases in Airway Smooth Muscle Cell Migration for the Process of Airway Remodeling
airway remodeling cell migration fibronectin matrix metalloproteinases smooth muscle cells
2010/11/12
The response of bSMC migration to bSMC-conditioned medium increased with time in culture, and fibronectin (FIB) was detected as a chemoattractant for bSMCs in bSMC-conditioned medium by western blot a...
Expression and Function of the Inducible Costimulator Ligand B7-H2 in Human Airway Smooth Muscle Cells
airway inflammation airway smooth muscle cells B7-H2 DNA synthesis inducible costimulator
2010/11/16
The data demonstrate that ASM cells express functionally active B7-H2, CD40 and OX40L and suggest that B7-H2-dependent signaling may play an active role in a proliferative response rather than in cyto...
Remodeling of Airway Walls in Fatal Asthmatics Decreases Lymphatic Distribution; Beyond Thickening of Airway Smooth Muscle Layers
airway-remodeling bronchial asthma lymphangiogenesis lymphatic capillary mucosal edema
2010/11/17
These results indicate that distribution of lymphatics were decreased in the airway walls of fatal asthmatics which contained muscle bundles and fibro-connective tissues both of which were augmented i...
Airway Remodeling and Airway Smooth Muscle in Asthma
airway hyperresponsiveness hyperplasia hypertrophy in vitro in vivo
2010/11/19
Airway remodeling in asthma has been recognized as structural changes of airways such as smooth muscle hypertrophy (an increase in size of airway smooth muscle cells) and hyperplasia (an increase in t...
Airway Smooth Muscle and Asthma
airway remodelling airway smooth muscle asthma extracellular matrix inflammation
2010/11/19
The airway smooth muscle is the key determinant of airway narrowing in asthma but its function in the absence of disease is unknown. Evidence for an intrinsic abnormality in the muscle in asthma is on...
Mechanical strain-induced DNA synthesis and cell proliferation in human airway smooth muscle cells through extracellular signal-regulated kinase
airway smooth muscle cell extracellular signal-regulated kinase mechanical strain
2010/11/25
An increased airway muscle content is one of the characteristic features of airway remodeling. Proinflammatory substances, growth factors and mechanical strain promote airway muscle cell proliferation...
Inhalant corticosteroids inhibit mechanical strain-induced RANTES and eotaxin production by human airway smooth muscle cells
airway smooth muscle cells eotaxin inhaled corticosteroids mechanical strain RANTES
2010/11/24
The results showed that: (i) mechanical strain, including stretch and compression, stimulated ASM cells to produce RANTES and eotaxin; and (ii) FP and BUD inhibited mechanical strain-induced and TNF-α...