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Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
SARS-CoV-2 human ACE2 transgenic mouse COVID-19 pneumonia
2020/6/11
COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angi...
Scientists have successfully regenerated cells in the retina of adult mice at the University of Washington School of Medicine in Seattle.Their results raise the hope that someday it may be possible to...
Ovariectomy increases squamous metaplasia of the uterine horns and survival of SENCAR mice fed a vitamin A–deficient diet
ovariectomy survival vitamin A deficiency
2016/6/1
Retinoic acid is necessary for the growth and differentiation
of organisms and exerts its molecular actions by
binding to specific nuclear receptors that belong to the thyroidsteroid
hormone recept...
Microcurrent Electrical Neuromuscular Stimulation Facilitates Regeneration of Injured Skeletal Muscle in Mice
Muscle injury regenerative potential
2015/8/28
Conservative therapies, mainly resting care for the damaged
muscle, are generally used as a treatment for skeletal muscle
injuries (such as muscle fragmentation). Several past studies
reported t...
Efflux of Creatine Kinase from Isolated Soleus Muscle Depends on Age, Sex and Type of Exercise in Mice
Skeletal muscle eccentric contractions muscle damage CK activity
2015/8/28
Elevated plasma creatine kinase (CK) activity is often used as an
indicator of exercise-induced muscle damage. Our aim was to
study effects of contraction type, sex and age on CK efflux from
iso...
Proteomic analysis of plasma after branched chain enriched mixture supplementation in mice
Amino acids Proteome Dietary supplements
2015/7/27
Branched chain amino acid (BCAA) supplementation is a recently identified strategy to promote longevity in mice. A proteomic approach was used to identify proteins which are differentially expressed i...
RNA Synthesis in the Tracheal Epithelial Cells of Aging Mice as Revealed by Electron Microscopic Radioautography
RNA synthesis Macromolecular Microscopic radioautography 3H-uridine
2015/7/21
For the purpose of studying the aging changes of macromolecular synthesis in the tracheal epithelial cells of experimental animals, we studied 10 groups of aging mice during development and aging from...
Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
STAT6VT transgenic Atopic Dermatitis
2015/5/25
Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the dis...
Nf1-DEFICIENT MICE DISPLAY SOCIAL LEARNING DEFICITS THAT ARE RESCUED BY THE DELETION OF PAK1 GENE
Neurofibromatosis type 1 (NF1) social learning p21-activated kinase 1 (PAK1) MAPK prefrontal cortex basolateral amygdala
2015/5/21
Neurofibromatosis type 1 (NF1) is a neurocutaneous disorder that affects roughly 1 in 3500 individuals. In addition to physical features (e.g., neurofibromas), developmental disorders are also common ...
THE EFFECT OF ETHANOL ON IMPULSIVITY IN HIGH ALCOHOL PREFERRING MICE
ETHANOL HIGH ALCOHOL PREFERRING MICE
2015/5/21
Impulsivity is associated with addiction in many human studies. Delay discounting (DD) is often used to measure impulsive choice in humans and animals. In DD testing, a small immediate reward is pitte...
Loss of Adipocyte VEGF Impairs Endurance Exercise Capacity in Mice
INSULIN FREE FATTY ACIDS GLYCEROL SKELETAL MUSCLE WHITE ADIPOSE TISSUE
2017/4/20
Purpose: Reducing vascular endothelial growth factor (VEGF) in adipose tissue alters adipose vascularity and metabolic homeostasis. We hypothesized that this would also affect metabolic responses duri...
Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice
INFLAMMATION MACROPHAGE ACUTE EXERCISE ADIPOSE TISSUE
2017/4/20
Introduction: Adipose tissue insulin action is impaired in obesity and is associated with inflammation, macrophage infiltration, and polarization toward a proinflammatory phenotype. Acute exercise can...
Lithium effects on ethanol intake in impulsive mice
lithium ethanol mice intakes pharmacological manipulation
2015/1/9
The present study sought to identify the effects of chronic lithium administration on ethanol intakes in high alcohol-preferring (HAP) mice. Lithium is a well-established treatment for bipolar disorde...
Intravenous Self-Administration of Alcohol in Selectively Bred High- and Low- Alcohol Preferring Mice
Genetic vulnerability alcoholism gene alcohol dependence animal model genetic vulnerability
2015/1/9
Genetic vulnerability to alcoholism is theorized to be caused by multiple interacting genetic loci, each with a small to modest effect combining under certain environmental influences to contribute to...
Exercise-Induced Changes in the Cortical Bone of Growing Mice Are Bone and Gender Specific
mechanical properties pQCT matrix changes
2014/12/4
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to no...