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Comparative Cytotoxicity of Fludarabine in Human Peripheral Blood Mononuclear Cells and in the Promyelocytic Leukemia Cell Line (HL60)
HL60 MTT assay fludarabine cytotoxicity differentiation
2009/6/23
Fludarabine is an inhibitor of DNA/RNA synthesis with antitumor activity on lymphoproliferative malignancies. We investigated the dose-dependent cytotoxic effects of the drug on human peripheral blood...
Chlorambucil and fludarabine as a new pre-transplant conditioning for patients with chronic lymphocytic leukemia: results of in vivo experiments
rat haematological toxicity non-haematological toxicity
2015/3/17
Chronic lymphatic leukemia (CLL), incurable by standard treatments, may be potentially cured by
allogeneic hematopoietic stem cell transplantation. Since CLL affects predominantly older people, ther...