搜索结果: 1-8 共查到“医学遗传学 Cell”相关记录8条 . 查询时间(0.125 秒)
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2019年12月10日,来自北京大学基础医学院的张宏权教授团队在Cell Reports杂志上在线发表题为Kindlin-2 inhibits Hippo signaling pathway via promoting degradation of MOB1的长篇研究论文。该研究发现整合素相互作用蛋白Kindlin-2能够通过促进MOB1的降解抑制Hippo信号通路,进而延缓肾纤维化的疾病进程。H...
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染色体的完整性和遗传信息的精准传递对于细胞以及个体而言至关重要,而放射损伤所导致的DNA双链断裂会直接导致染色体的断裂、丢失和重排,如不能及时修复则会导致细胞的死亡或者癌变。MRN(MRE11/RAD50/NBS1)复合体在放射损伤修复通路中扮演着重要的角色,该复合体作为DNA损伤的“感应器”最先识别DNA双链断裂的位点:一方面,MRN可以引起ATM磷酸化级联反应,激活细胞周期检验点;另一方面,M...
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山东大学基础医学院青年教师胡慧丽研究成果在Cell发表(图)
山东大学基础医学院 青年教师 胡慧丽 Cell
2018/12/14
近日,实验畸形学教育部重点实验室、山东大学基础医学院遗传学系青年教师胡慧丽作为第一作者完成的学术论文“Long-term expansion of functional mouse and human hepatocytes as 3D organoids”被Cell接收并发表(Volume 175, 1591–1606)。本项研究为胡慧丽在荷兰皇家科学院Hubrecht研究所做为博士后访学期间完...
Seeing Cell to Cell Differences for First Time Explains Symptoms of Rare Genetic Disorders,Finds Penn Study
Cell Differences Rare Genetic Disorders
2016/4/13
Every cell in the body has two genomes, one from the mother and one from the father. Until now, researchers have lacked the tools to examine -- in a single cell --the exact readout from each genome to...
Vitamin D Dependent Down Regulation of Arf1 Gene in Human Leukemia Cell Line HL-60
Gene expression ARF1 Vitamin D Real-Time RT-PCR
2009/6/24
ADP-ribosylation factor 1 (ARF1) is a gene belonging to the ARF gene family. ARF genes, small guanine nucleotide-binding proteins, constitute a family of the RAS superfamily. This superfamily function...
用间期荧光原位杂交检测卵巢癌细胞中X染色体数目的异常The Application of Interphase Fluorescence in situ Hybridization to the Diagnosis of X Chromosomal Count Abnormality in Ovarian Carcinoma Cell
荧光原位杂交 卵巢癌 X染色体数目异常 DNA特异性探针
2008/1/10
摘要为了探讨用荧光原位杂交技术(fluorescence in situ hybridization, FISH)检测卵巢癌细胞中性染色体拷贝数目异常的实验方法及其应用价值,收集18例新鲜卵巢癌组织标本,以Biotin标记的X染色体α-卫星DNA(pBamX7)探针与经处理的标本进行卵巢癌细胞核的原位杂交,分别用Avidin-FITC和Anti-avidin进行信号的检测与放大,PI复染。于Oly...
CNE1、CNE2鼻咽癌细胞株中ATM/PI3K区基因突变的检测Study on Mutation of ATM/PI3K Region in NPC Cell Lines with Different Radiosensitivity
鼻咽癌 ATM 放射敏感性
2007/12/30
摘要为了探讨具有不同放射敏感性的CNE1、CNE2鼻咽癌细胞株中ATM/PI3K区基因突变的情况,采用反转录聚合酶链式反应(RT-PCR)技术和PCR产物直接测序方法(荧光标记的ddNTPs循环测序),对CNE1、CNE2中ATM的PI3K关键区域进行突变检测。结果表明,所测CNE1、CNE2中的ATM/PI3K区序列中没有发生突变,认为鼻咽癌细胞株CNE1、CNE2间内在的放射敏感性的差异可能与...
Arsenic Trioxide Compound Modulates Multiple Myeloma Phenotypes: Assessment on Cell Line Models
Multiple myeloma Karpas 707 MMP-2 Angiogenesis Apoptosis Cytotoxicity Arsenic trioxide
2010/2/3
Recent evidences suggest that multiple myeloma phenotypes (MMPs) are involved in the infiltration of multiple myeloma-affected marrow foci. In this study, the effects of arsenic trioxide on the invasi...