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探讨儿童支气管哮喘严重程度与血清嗜酸粒细胞阳离子蛋白(eosinophil cationic protein，ECP)、总IgE(Total IgE，TIgE)、嗜酸粒细胞(eosinophils，EOS)水平的关系;了解儿童支气管哮喘常见过敏原，为儿童支气管哮喘的预防、病情判断及治疗提供依据。方法 据儿童哮喘严重程度分级标准将95例哮喘患儿分为间歇发作组(n=23)、轻度组(n=29)、中度组(...
Lipocalin-Type Prostaglandin D Synthase and Egg White Cystatin React with IgE Antibodies from Children with Egg Allergy
cystatin food allergy hen's egg white LC-MS/MS lipocalin-type prostaglandin D synthase
2010/11/12
Background: Ovalbumin, ovomucoid, ovotransferrin, lysozyme, and ovomucin are known to be major allergens found in egg white. Egg white protein is composed of over 30 proteins; many of which have neith...
Osteopontin: A Potential Biomarker for Successful Bee Venom Immunotherapy and a Potential Molecule for Inhibiting IgE-mediated Allergic Responses
biomarker clustering mechanism microarray osteopontin (OPN) venom immunotherapy (VIT)
2010/11/19
Venom immunotherapy (VIT) is proven to be curative for insect allergy, but the mechanisms and the biomarkers associated with clinical efficacy remain elusive. We report herein the discovery of a leadi...
Sequential IgE epitope analysis of a birch pollen allergen (Bet v1) and an apple allergen (Mal d1)
apple Bet v1 birch immunotherapy Mal d1 sequential IgE epitope
2010/11/25
Cross-reactivity in IgE epitopes and T cell epitopes has been reported between major birch pollen allergen (Bet v1) and major apple allergen (Mal d1). To treat people with birch pollinosis complicated...
Evaluation of two grass pollen extracts for immunotherapy by serum determinations of specific IgE and IgG4 antibodies towards purified Timothy grass pollen allergens (Phl p 1, 2, 4, 5, 6, 7, 11, 12) in patients undergoing hyposensitization treatment
allergen immunotherapy IgE grass pollen allergy IgG4 subclass recombinant allergens
2010/11/24
These results indicate that grass pollen immunotherapy elicits an array of antibody specificities that reflect the allergen content and the potency of allergen extracts; this could be of pivotal impor...