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Atopic dermatitis, a common skin condition affecting both children and adults, is often thought of as an inflammatory disease that arises from a breakdown in the barrier function of the skin. Now a ne...
Background: It has been reported that measurements of eosinophil-derived neurotoxin (EDN) may be useful for identifying eosinophil activities in allergic diseases including atopic dermatitis. Methods...
We established a highly efficient, highly reproducible protocol to induce skin lesions in NC/Nga mice and successfully applied it to show the efficacy of terreic acid in treating skin lesions. This mo...
Background: Combination of suplatast tosilate with tacrolimus ointment was reported to reduce the dose of tacrolimus ointment with maintained treatment efficacy for refractory facial erythema in atopi...
Anti-IgE and anti-FcεRI α chain auto-antibodies have been detected in the sera of atopic and non-atopic subjects; however, the biological activity of these auto-antibodies is still unclear. These two ...
Background: In the present study, we tried to clarify whether nuclear hypersegmentation of peripheral blood eosinophils is correlated with peripheral eosinophil counts and/or the activity of atopic de...
The patch test positivity rate increased in proportion with the duration of antigen application, with a maximum of 15.6% for mite antigen and a minimum of 4.7% for cedar antigen by 72 h. There were no...
The plasma IL-18 level was elevated, particularly in patients with atopic dermatitis. As the clinical severity of atopic dermatitis increased, the plasma IL-18 level also tended to increase. These fin...
Interferon-γ and interleukin (IL)-12 pro-duction increased significantly after 2 weeks treatment (P < 0.005 and P < 0.05, respectively), while IL-10 production decreased significantly after 2 and 4 we...
It is suggested that repeated contact allergic dermatitis or mental stress may promote the development and exacerbation of AD and that substance P has a role in this response. In addition, it seems th...
In the treatment of atopic dermatitis ultraviolet therapy is considered the second line of treatment, when adverse reactions occur and control is difficult with topical steroid treatment given as firs...
We summarized the Therapeutic Guidelines for Atopic Dermatitis 2002, and outlined important points with reference to medical care and management of atopic dermatitis.
The total number of new attendant patients diagnosed as having atopic dermatitis at our dermatology out-patient clinic during the 7 year period from 1989 to 1995 was 10 156. Patients from each year du...
To analyze the development of antigen-specific IgE in infants and its clinical usefulness, the levels of IgE antibodies against egg white (f1) and cows' milk (f2) in 33 sera from cord blood, 118 sera ...

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