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阿比特龙联合恩度对人激素敏感性前列腺癌细胞增殖及VEGF-A和PSA水平的影响
前列腺肿瘤 病理学 药物疗法 细胞增殖 药物作用 内皮抑素类 投药和剂量 血管生成诱导剂 血管抑制素类 血管内皮生长因子A/代谢 前列腺特异抗原 代谢 肿瘤细胞
2020/8/14
探讨阿比特龙联合恩度对前列腺癌LNCaP细胞增殖及培养液上清中血管内皮生长因子A(vascular endothelial growth factor A,VEGF-A)及前列腺特异性抗原(prostate specific antigen,PSA)水平的影响。方法 将体外培养的LNCaP细胞分为无药物干预的对照组及不同浓度阿比特龙(0.1、1、10和100 μmol/L)、恩度(0.1、1、10...
Advances in the imaging of the prostate in the setting of elevated PSA levels
Mirror treatment prostate cancer imaging disease prostate specific membrane antigen receptors
2017/2/22
Mirroring exciting advances in the treatment of prostate cancer, advanced imaging techniques are providing improved detection and staging of this disease. Whereas treatment decisions were previously o...
Estimating the benefits and harms of PSA testing in the Australian Context
benefits and harms PSA testing Australian
2015/4/17
Results from international randomised controlled trials have been inconsistent as to whether prostate specific antigen (PSA) testing is associated with a mortality benefit. However, the PSA test is co...
Clinical practice guidelines for PSA testing and early management of test-detected prostate cancer
PSA testing early management test-detected prostate cancer
2015/4/17
There is a consensus among relevant peak professional bodies, government and non-government organisations in Australia, that Australian clinical practice guidelines for prostate specific antigen (PSA)...
Men over the age of 50 are often advised to “know their PSA”, with the implicit assumption that screening for prostate cancer is effective in reducing morbidity and/or mortality. Likewise men who have...
PSA启动子介导的TAT-p21WAF1/CIP1融合蛋白在前列腺癌细胞中的特异表达及活性初探*
前列腺特异抗原 TAT-p21WAF1/CIP1融合蛋白 前列腺肿瘤 LNCaP细胞 HT-29细胞
2009/6/8
目的:设计并构建含有前列腺组织特异性抗原(PSA)启动子的TAT-p21WAF1/CIP1融合蛋白真核表达载体(pPSA-TAT-p21),使由TAT蛋白转导结构域(TAT)介导的抑癌基因蛋白p21WAF1/CIP1(p21)能够在前列腺癌细胞中实现特异性的跨膜转运,增强p21对前列腺癌的抑制作用。方法:利用PCR技术构建含有PSA启动子、TAT蛋白转导序列和p21读码框架的真核表达载体pPSA-...
研究荧光磁性纳米粒子与前列腺癌特异性抗原(prostate cancer specific antigen,PSA)单链抗体片段结合的复合纳米探针作为前列腺癌核磁共振靶向显像剂与治疗剂的可行性。方法:荧光磁性纳米粒子(FMCNPs)与前列腺癌特异性单链抗体片段(ScFv)桥联制备成复合纳米探针(FMCNPs ScFv),应用高分辨电镜、荧光光谱仪与磁强度计进行鉴定。将FMCNPs ScFv与前列腺...
血清T-PSA 及F-PSA 检测对乳腺癌的诊断价值
乳腺癌 PSA 诊断
2014/1/8
前列腺特异抗原(Prostate-specific antigen,PSA)是分子量为30KD的单链糖蛋白,属于丝氨酸蛋白酶,由人类前列腺激肽释放酶基因家族成员之一HKLK3所编码,主要由前列腺管状上皮细胞合成。当某些病理改变使前列腺组织结构遭到破坏,PSA经过基质由毛细血管及淋巴结进入血液循环,而使血清PSA浓度增高。PSA自发现以来已成为最有效的前列腺肿瘤标志物,并在前列腺癌的诊断及治疗中起着...