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Thwarting Metastasis by Breaking Cancer’s Legs with Gold Rods
Thwarting Metastasis Breaking Cancer’s Legs Gold Rods
2017/7/24
“Your cancer has metastasized. I’m sorry,” is something no one wants to hear a doctor say.Cancer cells kill most often by crawling away from their original tumors to later re-root in vital parts of th...
2017冷泉港学术会议：癌症生物学（Cold Spring Harbor conference on Biology of Cancer: Microenvironment & Metastasis）
Diagnostic Imaging Cancer Immunology
2017/1/16
We are pleased to announce the fourth Cold Spring Harbor Laboratory meeting on the Biology of Cancer: Microenvironment & Metastasis. The meeting will begin on the evening of Tuesday October 10, 2017,...
Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
tissue transglutaminase TGF-beta ovarian cancer
2015/5/25
Ovarian cancer (OC) is a lethal disease due to metastasis and chemoresistance. Our laboratory previously reported that tissue transglutaminase (TG2) is overexpressed in OC and enhances OC peritoneal m...
siRNA-toting nanoparticles inhibit breast cancer metastasis
siRNA-toting nanoparticles inhibit breast cancer metastasis
2015/5/25
Researchers at Case Western Reserve University combined finely crafted nanoparticles with one of nature’s potent disrupters to prevent the spread of triple-negative breast cancer in mouse models.The h...
Intratumour heterogeneity in the progression to breast cancer metastasis
Intratumour heterogeneity breast cancer metastasis
2015/4/14
Unlike the great advances that have been made in reducing breast cancer mortality through the multidisciplinary treatment of primary disease, much less is understood about the natural history of metas...
Bone microenvironment and its role in bone metastasis
Bone microenvironment bone metastasis
2015/4/14
Bone is a common site for cancer metastasis. The development of bone metastases represents a serious progression in a patient with cancer, leading to treatment goals changing from curative to palliati...
Cancer progression is characterised by extensive metabolic reprogramming. Renewed enthusiasm in this field has been sparked in part by the realisation that metabolic pathways, oncogenes and tumour sup...
Survival after breast cancer diagnosis and treatment has improved markedly, however recurrence is still a treatment challenge for clinicians. The underlying cause for late recurrence after a long dise...
Tumour cells secrete small membrane vesicles (30-100nm) termed exosomes, that are derived from late endosomal compartments of cells. Exosomes are increasingly being recognised for their role in interc...
Disparate functions of myeloid-derived suppressor cells in cancer metastasis
Disparate functions cancer metastasis
2015/4/14
Myeloid-derived suppressor cells comprise a heterogeneous population of immature immune cells that expand during the course of cancer progression. These cells adopt an immunosuppressive phenotype that...
It has been 40 years since Folkman抯 seminal paper [Cancer Res 1974. 34:2109-13], proposing the presence of a tumour associated angiogenic factor, which could be targeted as an anticancer therapy. Ther...
Cancer remains a major cause of mortality, chiefly through metastatic spread of tumour cells to distant organs via the blood vascular or lymphatic circulations. The latter system has been more recentl...
Cancer arises from the deregulation of intracellular signaling pathways leading to uncontrolled cell proliferation and tumour formation. In many cases, cancer cells in the primary tumour disseminate a...
Leptomeningeal metastasis (LM) is usually a late complication of cancer, often accompanying systemic relapse of tumour. LM can affect any part of the neuraxis. It may seed the leptomeninges diffusely...
Surgical Therapeutic Strategy for Non-small Cell Lung Cancer with Mediastinal Lymph Node Metastasis (N2)
Lung neoplasms Thoracic surgical procedures Lymphatic metastasis Treatment outcome
2013/12/9
Background and objective Approximately 30% of patients who are diagnosed with non-small cell lung cancer (NSCLC) are classified as N2 on the basis of metastasis to the mediastinal lymph nodes. The eff...