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Determining the sulfur amino acid (SAA) requirements of humans has remained elusive because of the complex nature of SAA metabolism. Current recommendations are based on nitrogen balance studies.
Although plasma total homocysteine has been identified as an independent risk factor for vascular disease in a multitude of studies, there is a considerable overlap in values between patients at ri...
In an earlier study, using a modification of the indicator amino acid oxidation approach, we concluded that the 1985 FAO/WHO/UNU–proposed lysine requirement of 12 mg·kg1 ·d1 is likely inadequate to...
The currently accepted total aromatic amino acid requirement for adults is based on nitrogen balance measurements in individuals who received their intake of aromatic amino acids solely as phenylal...
The validity of the body mass index (BMI) as an indicator of the risk of becoming overweight and of the presence of overweight was evaluated in 6 groups of adolescents comprising several ethnic gro...
It is widely accepted that elevated plasma total homocysteine is an independent risk factor for vascular disease. The relation is believed to be causal, but there is no generally accepted mechanism fo...
Background:It has been hypothesized that the response of holo-transcobalamin (holo-TC) to oral vitamin B-12 may be used to assess absorption. To develop a reliable clinical absorption test that uses h...
Halfway through the past century, experiments in humans showed that a high dietary intake of saturated fat increased blood concentrations of cholesterol, which was later proven to be a key risk factor...
The 1985 FAO/WHO/UNU upper requirement for the sulfur-containing amino acids in healthy adults, which was set at 13 mg ?kg−1 ?d−1, is based on nitrogen balance studies in Western subjects....
In earlier studies with well-nourished subjects that used a 24-h indicator amino acid oxidation or balance approach, we concluded that the 1985 FAO/WHO/UNU requirement for lysine (12 mg · kg−1 ·...
Serum thyroglobulin appears to be a sensitive marker of thyroid dysfunction in endemic goiter. However, its value as an indicator of thyroid status in children after the introduction of iodized salt h...
Background: We previously questioned the validity of the 1985 FAO/WHO/UNU upper requirement value for threonine (7 mg · kg−1 · d−1) and proposed a tentative mean requirement of 1...
Background: The mean lysine requirement of healthy Indian subjects was estimated from short-term experimental diet periods to be 29 mg · kg−1 · d−1, which is higher than the 1985...
Background: Ketogenic diets are used therapeutically to treat intractable seizures. Clinically, it appears that the maintenance of ketosis is crucial to the efficacy of the diet in ameliorating s...
Background: Because we question the validity of the 1985 FAO/ WHO/UNU upper requirement for threonine of 7 mg·kg−1·d−1, we proposed a tentative mean requirement of 15 mg·kg−1·d&...

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