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Inhibiting protein clearance to induce cell death in tuberous sclerosis and pancreatic cancer
Ral 4-phenylbutyric acid 4-PBA
2015/5/25
Sequestration at the aggresome and degradation through autophagy are two approaches by which a cell can counteract the toxic effect of misfolded proteins. Tuberous sclerosis (TS) and cancer cells can ...
ADF/Cofilin Activation Regulates Actin Polymerization and Tension Development in Canine Tracheal Smooth Muscle
dissertations research thesis
2015/5/22
The contractile activation of airway smooth muscle tissues stimulates actin polymerization and the inhibition of actin polymerization inhibits tension development. Actin depolymerizing factor (ADF) an...
USING AIRBORNE HYPERSPECTRAL IMAGERY TO ESTIMATE CHLOROPHYLL A AND PHYCOCYANIN IN THREE CENTRAL INDIANA MESOTROPHIC TO EUTROPHIC RESERVOIRS
Remote Sensing Phycocyanin
2015/1/16
This thesis presents the results of an analysis of predicting phytoplankton pigment concentrations (chlorophyll a and phycocyanin) from remotely sensed imagery. Hyperspectral airborne and hand-held re...
B cell development and immunoglobulin genes in cattle
Cellular immune globulin genes immune system lymphoid tissue immunoglobulin molecules
2014/12/11
The objective of this dissertation was to study B cell development and the mechanism of immunoglobulin gene diversification in cattle. The bovine immune system differs from that of the mouse and human...
Follicle cell calmodulin: transcript accumulation in vitellogenic follicles of {\it Blattella germanica\/} is regulated by juvenile hormone
Calmodulin cells calmodulin oocytes vitellogenesis early embryo
2014/12/11
Calmodulin (CaM) is a major intracellular calcium receptor. There is abundant calmodulin (CaM) in the oocytes and eggs of B. germanica during vitellogenesis and early embryogenesis. The accumulation o...
Characterization and phosphorylation of an MPM-2 reactive sperm protein complex involved in zygotic aster formation
Sperm tubes egg quality microtubules female pronucleus male pronucleus fertilized egg triplet protein
2014/12/11
The zygotic centrosome, contributed by the sperm, forms an array of microtubules that spread throughout the ooplasm. These microtubules are used by the female pronucleus to come into juxtaposition wit...
Effects of amino acid substitution on chain packing in genetically engineered periodic polypeptides
Polymer materials biological protein protein polymers tyrosine crystal cell protein e. coli
2014/12/11
Architecturally well-defined polymeric materials with precisely controlled chain length, sequence, stereochemistry and interchain interactions can be produced using the fidelity of biological protein ...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Regulation of the actin cytoskeleton in the pollen tube
Pollen tube ovule sperm plant sexual reproduction actin cytoskeleton protein
2014/12/11
Pollen tube growth, the process that transports the sperm cell to the ovule, is fundamental for plant sexual reproduction. The actin cytoskeleton is essential to the process of pollen tube elongation....
Characterization of the yolk protein lipovitellin and its developmental fate in embryos and larvae of winter flounder, Pleuronectes americanus
Yolk lipid phosphoprotein vertebrates egg yolks protein egg yolk lipid phosphoprotein fertilized egg polypeptide etc
2014/12/11
Lipovitellin, the predominant yolk protein of vertebrate eggs, is a mixture of heat-stable and heat-labile molecules in mature winter flounder eggs. The heat-stable lipovitellin fraction, purified fro...
Structural changes between signaling states of bacterial chemoreceptors probed by solid -state NMR and hydrogen exchange
Structure of membrane protein lipid environment membrane signals bacteria chemical sensors membrane domains solid-state nuclear magnetic resonance (NMR)
2014/12/11
The limitations of structural studies of membrane proteins imposed by the lipid environment has made it difficult to determine the molecular mechanism of transmembrane signaling. For the bacterial che...
Structural and functional characterization of the unique N-terminus of Cse4p, A histone H3 -like protein at the S. cerevisiae centromere
Budding yeast the yeast protein protein fission yeast etc
2014/12/11
The budding yeast (S. cerevisiae) centromere component, Cse4p is an evolutionarily conserved histone H3-like protein, with homologues identified in fission yeast, worm, fly and human. All histone H3-l...
Diversification of the bovine primary immunoglobulin heavy chain repertoire: Ontological and hypermutational analyses in fetal and neonatal animals
Immune globulin reproductive gene the early fetus VH genes
2014/12/11
The objective of this dissertation was to identify and characterize diversity within the expressed primary immunoglobulin heavy chain (IgH) repertoire in cattle. Determinations relied heavily upon dif...
When stress is good: Exercise and stress protein responses in mice and humans
Skeletal muscle protein molecular changes protein heat shock protein biceps
2014/12/11
Eccentric contractions promote short- and long-term adaptations in skeletal muscle proteins, but little is known of molecular alterations associated with these changes. The present work investigated a...
The role of N -linked glycans in protein quality control in the early secretory pathway
ER quality protein abnormal protein protein degradation the cavity cytosol proteasome chitosan tyrosine
2014/12/11
The ER quality control machinery maintains the fidelity of the protein maturation process by sorting aberrant proteins for ER-associated protein degradation (ERAD), a process requiring retranslocation...