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Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
探讨失效模式效应分析在新型冠状病毒肺炎疫情期间社区居家护理感染防控中的应用效果。方法 新型冠状病毒肺炎疫情期间（2020年1—3月）在社区健康服务中心居家护理过程中运用失效模式效应分析找出潜在失效模式并制定改进措施,比较失效模式效应分析实施前（1月18—24日）和实施后（3月1—7日）感染风险值及感染防控相关措施落实情况,统计实施期间（1月25日—2月29日）医患双方新型冠状病毒肺炎感染率和服务患...
Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19
Plasma Metabolomic Lipidomic Alterations Associated COVID-19
2020/6/11
The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe conditions. However, the physiological changes asso...
The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
The anti-influenza virus drug arbidol efficient inhibitor SARS-CoV-2 in vitro
2020/6/11
Since December 2019, a novel disease COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread to over 200 countries and infected over 1.50 million people includin...
探讨非定点医院重症医学科(ICU)接收新型冠状病毒肺炎疑似病例时的感染防控及工作要求，为规范防控提供依据。方法 对绵阳市中心医院重症医学科2020年1月17日收治的1例新型冠状病毒肺炎疑似病例的收治、隔离、诊治过程进行分析，特别关注患者隔离、医务人员隔离及全病区隔离时的紧急隔离流程建立和运行。
As of March 10, 2020, the 2019 novel coronavirus (SARS-CoV-2) has been responsible for more than 110,000 infections and 4000 deaths worldwide, but data regarding the epidemiologic characteristics and ...
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Structure-based design antiviral drug candidates targeting SARS-CoV-2 protease
2020/6/12
SARS-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak. The main protease (Mpro) of SARS-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and tr...
Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019
coronavirus disease-19 (COVID-19) RNAemia IL-6 critically ill patients cytokine storm
2020/6/12
Although the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in respiratory specimens has been widely used to diagnose coronavirus disease 2019 (COVID-19), it is u...
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
SARS-CoV-2-encoded nucleocapsid protein acts viral suppressor of RNA interference cells
2020/6/12
We thank Prof. Peng Zhou (Wuhan, China) for kindly providing materials and thank Yan Wu and Weijuan Shang for experimental assistance. This work was supported by the Strategic Priority Research Progra...
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Structure Mpro SARS-CoV-2 discovery inhibitors
2020/6/12
A new coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the aetiological agent responsible for the 2019–2020 viral pneumonia outbreak of coronavirus disease 2019 (...
Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay
SARS-CoV-2 RT-LAMP COVID-19 Detection Visual
2020/6/12
To evaluate a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and compare it with RT-PCR.
Effectiveness of convalescent plasma therapy in severe COVID-19 patients
COVID-19 convalescent plasma treatment outcome pilot project
2020/6/12
Currently, there are no approved specific antiviral agents for novel coronavirus disease 2019 (COVID-19). In this study, 10 severe patients confirmed by real-time viral RNA test were enrolled prospect...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
Hydroxychloroquine less toxic derivative chloroquine effective inhibiting SARS-CoV-2 infection vitro
2020/6/12
The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local econom...