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Researchers Use DNA‘Clews’to Shuttle CRISPR-Cas9 Gene-Editing Tool into Cells
Researchers DNA Clews Shuttle CRISPR-Cas9 Gene-Editing Tool
2015/9/8
CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers the Cas9 protein...
Overexpression of a Hyperpolarization-Activated Cation Current (Ih) Channel Gene Modifies the Firing Activity of Identified Motor Neurons in a Small Neural Network
gene expression neuronal network
2015/8/25
Imputing Missing Data for Gene Expression Arrays
Imputing Missing Data Gene Expression Arrays
2015/8/21
Here we describe three different methods for imputation.The first is based on a reduced rank SVD of the expression matrix, the second is based on K-nearest neighbor averaging, and the third is based o...
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Gene expression patterns breast carcinomas tumor subclasses clinical implications
2015/8/21
The purpose of this study was to classify breast carcinomas based on variations in gene expression patterns derived from cDNA microarrays and to correlate tumor characteristics to clinical outcome. A ...
Averaged gene expressions for regression
Averaging Hierarchical clustering Lasso Variance reduction
2015/8/21
Although averaging is a simple technique, it plays an important role in reducing variance. We use this essential property of averaging in regression of the DNA microarray data, which poses the challen...
Penalized Logistic Regression for Detecting Gene Interactions
Penalized Logistic Regression Detecting Gene Interactions
2015/8/21
We propose using a variant of logistic regression with L2 regularization to fit genegene and gene-environment interaction models. Studies have shown that many common diseases are influenced by interac...
Regularization Path Algorithms for Detecting Gene Interactions
Path Algorithms Detecting Gene Interactions
2015/8/21
In this study, we consider several regularization path algorithms with grouped variable selection for modeling gene-interactions. When fitting with categorical factors, including the genotype measurem...
Skeletal muscle metabolic gene response to carbohydrate feeding during exercise in the heat
Mitochondrial biogenesis PGC-1α UCP3
2015/7/28
Heat stress down-regulates mitochondrial function, while carbohydrate supplementation attenuates
the exercise induced stimulation of mitochondrial biogenesis in humans. The effects of exogenous carbo...
Identification of a Leaf Rust Resistance Gene in the Chinese Wheat Line LB0288
leaf rust resistance gene molecular mapping wheat
2015/7/2
Leaf rust (LR), caused by Puccinia triticina (Pt), is worldwide one of the most spread diseases in common wheat
(Triticum aestivum L.). With the objective of identifying and mapping new genes for re...
Evaluation of the effectiveness of introducing new alleles into the gene pool of a rare dog breed: Polish Hound as the example
dog pedigree analysis mtDNA
2015/6/23
The results indicated
the very limited breeding success of such dogs in relation to their contributions to the gene pool and to the
number of their descendants used in breeding. Dogs of unknown or...
Many Experiments for the Price of One:A Breakthrough in the Study of Gene Regulation
Price of One Gene Regulation
2015/6/18
Inside every cell that makes up a diminutive fruit fly is a vast, dynamic network of information—the genome whose ~15,000 genes allow that cell to function. In a study recently published as a Br...
Missense mutations in exon 2 of the porcine leptin receptor gene and their associations with litter size and body weight
LEPR SNPs pigs
2015/6/8
Leptin receptor (LEPR) gene is regarded as a “candidate-gene” of production traits. The aims of this study were to detect polymorphisms of exon 2 within LEPR gene and to investigate their associations...
Porcine perilipin (PLIN) gene: Structure, polymorphism and association study in Large White pigs
pig perilipin polymorphism
2015/6/8
Perilipin, encoded by the PLIN gene, is a lipid droplet-associated phosphoprotein that functions as a key regulator of triacylglycerol storage and hydrolysis in adipocytes. In this study, structure an...
The visfatin (NAMPT; PBEF1) gene polymorphisms and associations with meat performance traits in three pig breeds kept in the Czech Republic
visfatin NAMPT PBEF
2015/6/8
Visfatin encoded by the NAMPT gene (nicotinamide phosphoribosyltransferase, formerly also known as PBEF ?pre-B cell colony-enhancing factor) is suggested to play a role in lipid metabolism and pathoph...
An MspI PCR-RFLP detecting a single nucleotide polymorphism at alpha-lactalbumin gene in goat
goat alpha-lactalbumin gene polymorphism Single Nucleotide Polymorphism (SNP) PCR-RFLP
2015/6/4
Alpha-lactalbumin (α-LA, LALBA) was strongly correlated with the nutritional value and the functional properties of whey and whey products. However, there are not many studies of goat LALBA gene and i...