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Parental obesity compared with serum leptin and serum leptin receptor levels among abese adults in the Gaza Strip
Parental obesity leptin soluble leptin receptor adult obesity the Gaza Strip
2010/1/12
Aims: To investigate whether parental obesity influences serum leptin hormone and soluble leptin receptor (Ob-Re) concentrations among obese adults in the Gaza Strip. Materials and methods: A case-con...
Variants of the peroxisome proliferator-activated receptor - and ß-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children
Children eating behavior energy compensation PPARG gene variants BMI body mass index
2008/12/17
Background: Young children can regulate energy precisely in the short term, showing the potential for an innate compensation mechanism of eating behavior. However, data suggest that precise compensati...
Functional Role of Hepatocyte Growth Factor Receptor During Sperm Maturation
C-met spermatozoa rat testis epididymis
2008/12/16
Mammalian spermatozoa acquire motility and fertilizing capacity during their transit through the epididymis. Hepatocyte growth factor (HGF) is a pleiotropic cytokine with potent motogenic capacities t...
Lack of Glutamate Transporter EAAC1 in the Epididymis of Infertile c-ros Receptor Tyrosine-Kinase Deficient Mice
Male reproductive tract gene chips sperm gamete biology cDNA arrays
2008/12/15
Transgenic male mice carrying inactive mutations of the receptor tyrosine kinase c-ros lack the caput epididymidis initial segment and are infertile because sperm volume regulation is compromised. Com...
Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Québec Family Study1,2,3
Adiponectin adiponectin receptor resting metabolic rate respiratory quotient obesity abdominal obesity
2008/12/12
Background: Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adipos...
A Double-Blind Non-inferiority Clinical Study of Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Compared with Pranlukast in Patients with Seasonal Allergic Rhinitis
comparative double blind study cysteinyl leukotriene receptor montelukast pranlukast seasonal allergic rhinitis
2010/11/17
Montelukast 5mg, 10mg once daily and the pranlukast 450mg/day showed significant improvements in the change from the baseline in the composite, daytime and nighttime nasal symptom scores, and the impr...
Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity1,2,3
MC3R gene polymorphism childhood obesity weight loss BMI z score
2008/12/11
Background:The central melanocortin system is critical for the long-term regulation of energy homeostasis. Melanocortin-3 receptor (MC3R) knock-out mice, despite being hypophagic, have increased fat m...
Puberty Is Delayed in Male Growth Hormone Receptor Gene—Disrupted Mice
Sexual development balanopreputial separation seminal vesicles insulin-like growth factor-I testosterone
2008/12/8
The role of insulin-like growth factor-I (IGF-I) in the initiation of puberty and testicular function is poorly understood. Growth hormone (GH) receptor (R) gene—disrupted mice or GHR gene "knocko...
Cholesterol Transport, Peripheral Benzodiazepine Receptor, and Steroidogenesis in Aging Leydig Cells
Mitochondria steroidogenic acute regulatory protein
2008/12/3
The cellular mechanisms responsible for age-related decline in the ability of Leydig cells to produce testosterone are not yet fully understood. The decline in testosterone production could result fro...
Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction
Pilot study endothelin-A receptor treatment erectile dysfunction
2008/12/1
Endothelins have been postulated to be important regulators of penile erectile function. The endothelin-A receptor antagonist BMS-193884 was evaluated as a treatment for mild-to-moderate erectile dysf...
Occlusal Stimuli Influence on the Expression of IGF-1 and the IGF-1 Receptor in the Rat Periodontal Ligament
Periodontal ligament Occlusal stimuli IGF-1 IGF-1 receptor Cell proliferation
2008/11/6
Objective: To test the hypothesis that hypofunction/recovered occlusal function has no effect on the changes in insulin-like growth factor-1 (IGF-1) and IGF-1 receptor expressions and cell proliferati...
Therapeutic Effect of Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, on Japanese Patients with Seasonal Allergic Rhinitis
cysteinyl leukotriene receptor dose-response relationship montelukast rhinitis allergic seasonal
2010/11/17
Background: Secretion of nasal discharge was enhanced and airway-resistance in the nasal cavity was augmented, resulting in nasal congestion, when leukotrienes were administered to the nasal mucosa. T...
α-Tocopherol modulates the low density lipoprotein receptor of human HepG2 cells
low density lipoprotein α-Tocopherol modulates
2008/4/23
The aim of this study was to determine the effects of vitamin E (α-tocopherol) on the low density lipoprotein (LDL) receptor, a cell surface protein which plays an important role in controlling blood ...
Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants
plasma leptin Developmental variations
2008/4/23
Leptin and its soluble receptor (sOB-R) are important to regulation of body composition but there are no data on the developmental variations in these plasma variables and their relationship with body...
磺酰脲类受体基因多态性与2型糖尿病的相关性研究Study on the Relationship between Sulfonylurea Receptor 1 Gene Polymorphism and Type 2 Diabetes Mellitus
2型糖尿病 磺酰脲类受体1 基因多态性
2008/1/10
摘要 研
究磺酰脲类受体1(SUR1)基因外显子16-3c/t多态性在中国某南方汉族人群中是否为2型糖尿病的致病基因座。采用聚合酶链反应-限制酶酶切片段长度多态性(PCR-RFLP)方法对南方汉族46个2型糖尿病高发家系成员的SUR1基因外显子16的多态性进行分析。利用Mantel-Haenszel分层分析研究该基因座多态性与2型糖尿病的关系。在高发家系人群中,SUR1基因外显子16-3c/t多...