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Immortalized testis cell lines from estrogen receptor（ER）alpha knock-out and wild-type mice expressing functional ERalpha or ERbeta
Immortalization HPV E6/E7 in vitro models
2008/12/29
The surprising findings that male mice lacking the estrogen receptor (ER) alpha (alphaERKO) have atrophic testis and are infertile proved that ERalpha is involved in normal testicular function. To o...
Intracavernosal pressure monitoring in mice：responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration
Intracavernosal pressure monitoring mice electrical stimulation intracavernosal drug administration
2008/12/25
With the development of transgenic mice to evaluate mechanisms of erectile function, it appears particularly advantageous to develop a standardized mouse model of penile erection. The purpose of the...
Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice
Morphologic changes efferent ductules epididymis estrogen receptor-alpha
2008/12/25
Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the ...
Mice Lacking Raf Kinase Inhibitor Protein-1 (RKIP-1) Have Altered Sperm Capacitation and Reduced Reproduction Rates With a Normal Response to Testicular Injury
PEBP testis
2008/12/24
Raf kinase inhibitor protein-1 (RKIP-1) belongs to the phosphatidyl ethanolamine–binding family of proteins (PEBP), which are highly conserved throughout evolution and widely expressed in tissues...
Abnormal Morphology of Spermatozoa in Cytochrome P450 17-hydroxylase/17, 20-lyase（CYP17）Deficient Mice
Gene deletion steroidogenesis mitochondria architecture fertility
2008/12/24
Cytochrome P450 17-hydroxylase/17, 20-lyase (CYP17) is crucial for cortisol and sex steroid biosynthesis. In a previous study we examined CYP17 function by generating mice with a targeted CYP17 d...
Prolonged Histamine Deficiency in Histidine Decarboxylase Gene Knockout Mice Affects Leydig Cell Function
Steroidogenesis human choriogonadotropin
2008/12/24
The present study focuses on histaminergic regulation of Leydig cell physiology, since limited information is available so far. To evaluate the dependency of Leydig cells on histamine (HA), we pe...
Irradiated Mouse Testes Efficiently Support Spermatogenesis Derived From Donor Germ Cells of Mice and Rats
Irradiation busulfan testis spermatogonial transplantation
2008/12/24
Testicular cell transplantation has been widely used to investigate the biology of spermatogonial stem cells, production of transgenic animals, and restoration of fertility in rodent models. O...
Overexpression of Endothelial Nitric Oxide Synthase in Transgenic Mice Accelerates Testicular Germ Cell Apoptosis Induced by Experimental Cryptorchidism
Immunoblotting TUNEL spermatocytes spermatids spermatogonia
2008/12/23
Surgical induction of cryptorchidism in experimental animals causes testicular germ cell apoptosis and infertility. The mechanisms of germ cell apoptosis have been associated with oxidative stress o...
Recapitulation of Germ Cell- and Pituitary-Specific Expression With 1.6 kb of the Cystatin-Related Epididymal Spermatogenic（Cres）Gene Promoter in Transgenic Mice
Epididymis testis spermatogenesis gene regulation
2008/12/23
The Cres (cystatin-related epididymal spermatogenic) gene encodes the defining member of a new subgroup within the family 2 cystatins of cysteine protease inhibitors. Cres expression is highly tis...
Cisplatin-Induced Long-term Failure of Spermatogenesis in Adult C57/Bl/6J Mice
Apoptosis testis germ cell Sertoli cell
2008/12/23
Exposure to cisplatin results in impaired spermatogenesis, azoospermia, and, sometimes, permanent infertility in male patients. The mechanism(s) by which cisplatin induces damage to testicular cells...
Nickel-Induced Oxidative Stress in Testis of Mice：Evidence of DNA Damage and Genotoxic Effects
Nickel chloride oxidative damage apoptosis abnormal sperms dominant lethal mutations
2008/12/22
Oxidative stress (OS) mechanisms are speculated to play a significant role in nickel-induced toxic effects and their carcinogenic potency. Although nickel-induced oxidative damage in somatic tissues...
Rapid Glucocorticoid Mediation of Suppressed Testosterone Biosynthesis in Male Mice Subjected to Immobilization Stress
Leydig cell cyclic AMP glucocorticoid receptor
2008/12/22
Physical and psychosocial stress challenge homeostasis, increasing glucocorticoid secretion (in rodents, corticosterone [CORT]) while decreasing testosterone (T) levels. The dynamics of stress-induc...
Effects of Putative Epididymal Osmolytes on Sperm Volume Regulation of Fertile and Infertile c-ros Transgenic Mice
Sperm swelling regulatory volume decrease quinine organic osmolytes infertility
2008/12/22
Volume regulation by spermatozoa has been demonstrated to be crucial in both mice and men for transport in the female tract. In order to determine the nature of osmolytes used by spermatozoa, they...
Chronic Administration of Atrial Natriuretic Peptide Reduces Testosterone Production of Testes in Mice
ANP spermatogenesis testosterone
2008/12/19
The purpose of the present study was to examine the effect of the long-term administration of human atrial natriuretic peptide (ANP) on testosterone production in male mice. Twenty-five mice recei...
Effect of Simulated Microgravity on Testosterone and Sperm Motility in Mice
Tail suspension space simulated weightlessness testicular function spermatogenesis mouse
2008/12/19
We examined changes in the serum testosterone level and in sperm in the testis and epididymis by using tail-suspended mice, which are a simulation model of the body fluid shift in space, to evalua...