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Aging Exacerbates Restraint Stress-Induced Inhibition of Antigen-Specific Antibody Production in Mice
aged mouse immunosuppression phospholipase A2 restraint stress specific antibody
2010/11/16
Background: We have recently found that exposure to acute restraint stress suppresses antigen-specific antibody production, including IgE, in a murine model of allergic rhinitis. Although age-related ...
Recent Knowledge Concerning Craniofacial Aging.
Testicular size：the effects of aging, malnutrition, and illness
aging malnutrition illness
2009/2/20
Paired testicular volumes and weights, as well as age, height, and weight, were recorded from a series of 1056 consecutive necropsies on adult males ranging in age from 18 to 96 years. These data we...
Testicular LH receptors during aging in Fisher 344 rats
LH receptors testicular tumors Fisher 344 rats aging
2009/2/20
Levels of serum LH, prolactin, testosterone, progesterone and 17-OH progesterone and the testicular concentration and total content of LH receptors were measured in 4-, 11-, 18-, and 27-month-old Fi...
The aging Leydig cell. VIII. Protein kinase activity
The aging Leydig cell Protein kinase activity
2009/2/19
The effects of aging on cyclic AMP (cAMP) dependent protein kinase activity of purified Leydig cells were evaluated. Purified Leydig cells from 20-day-, 40-day-, 60-day- and 30-month-old rats were...
Testis Vein Testosterone Falls in the Aging Rat：Refutation of“Dilution”Hypothesis
dilution hypothesis in aging testicular function ratio of testicular vein to peripheral serum testosterone
2009/2/19
A proposal that serum testosterone concentration declines during aging In the male laboratory rat because it is diluted in a larger body mass (and larger blood plasma volume) was reexamined. Five ag...
The Aging Leydig Cell: III. Gonadotropin Stimulation in Men
human aging Leydig cells testosterone 17OH-progesterone estradiol human chorionic gonadotropin
2009/2/19
To assess the capacity of aging human Leydig cells to respond to intramuscular injection of hCG, six healthy men, 68 to 86 years old, and eight healthy younger subjects, 25 to 42 years old, were s...
Aging in the AXC Rat：Androgen Regulation of Prostate Prolactin Receptors
aging rat prostate receptors prolactin
2009/2/18
Prolactin receptor content of ventral prostates of young mature (4-5-month-old), adult (12-13-month-old), and aged (24-27-month-old) untreated AXC rats was 677 ± 151, 826 ± 242, and 213 ± 59 (P < 0.01...
Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacement
Brown Norway rat accelerated germ cell apoptosis luteinizing hormone replacement
2009/2/18
Reproductive aging in the male Brown Norway (BN) rat is characterized by decreased Leydig cell steroidogenesis associated with seminiferous tubule dysfunction. This could be a result of a combination ...
The effects of aging on the seminiferous epithelium and the blood-testis barrier of the Brown Norway rat
seminiferous epithelium blood-testis barrier Brown Norway rat
2009/2/18
Steroidogenesis and spermatogenesis decrease in aging Brown Norway rats. We therefore hypothesized that there must be accompanying morphological changes taking place in the seminiferous tubules of...
The effects of aging on the expression of glutathione S-transferases in the testis and epididymis of the Brown Norway rat
glutathione S-transferases epididymis Brown Norway rat
2009/2/17
Glutathione S-transferases (GSTs), a family of isoenzymes, catalyze the conjugation of glutathione to a variety of electrophiles, and protect cellular constituents from electrophilic and oxidative...
Neuronal nitric oxide synthase in the canine prostate：aging, sex steroid, and pathology correlations
Testis imprinting BPH atrophy testosterone
2009/2/17
Nitric oxide synthase (NOS) is expressed in the prostate of various species, including humans. NOS catalyzes the production of nitric oxide (NO), which may function in prostatic smooth-muscle relaxa...
In the male brown-Norway (BN) male rat, reproductive aging is associated with decreased LH-pulse amplitude and area
FSH testosterone pulsatile secretion
2009/2/17
The Brown-Norway (BN) rat has been proposed as a rodent model for the study of human male reproductive aging. As in man, reduction in serum or plasma testosterone (T) and both testicular (primary)...
The number and magnitude of studies involving testosterone-supplementation therapy in older men are limited. In addition, many studies to date have not been blinded or controlled, were reported in...
Are Leydig cell steroidogenic enzymes differentially regulated with aging?
Leydig cells aging steroidogenesis
2009/2/16
Previous studies have shown that the ability of Brown Norway rat Leydig cells to produce testosterone declines significantly with age. To address the possible mechanism(s) by which aging Leydig cell...