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Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity
5-a-Reductase androgen receptor micropenis
2009/2/11
Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron-type dwarfism suggests that factors such as GH or insulin-like growth factor 1 (IGF-1) might in addition to ...
Role of nerve growth factor-like protein in the paracrine regulation of prostate growth
protein paracrine regulation prostate growth
2009/2/11
Prostate cancer is the most commonly diagnosed form of malignant neoplasia in men. Considerable evidence has accumulated suggesting that paracrine interactions between stromal cells and epithelial cel...
Effects of insulin-like growth factor-I on androgen production by highly purified pubertal and adult rat Leydig cells
Somatomedin-C development steroidogenesis
2009/2/10
Leydig cells were isolated and purified from adult and midpubertal rats to study the effects of insulin-like growth factor-I (IGF-I) on steroidogenesis. Androgen production, as measured in Leydig ce...
Expression, action, and regulation of transforming growth factor alpha and epidermal growth factor receptor during embryonic and perinatal rat testis development
FSH gametogenesis mesenchymal-epithelial Sertoli
2008/12/29
The objective of the current study was to extend previous observations and examine the expression pattern and effects of transforming growth factor alpha (TGFalpha) and epidermal growth factor recep...
Epidermal growth factor modulates the expression of vascular endothelial growth factor in the human prostate
Epidermal growth factor vascular endothelial growth factor human prostate
2008/12/26
The growth and dissemination of tumors in the body has been associated with angiogenesis. Vascular endothelial growth factor (VEGF) is an angiogenic factor that stimulates endothelial cell growth and ...
Effects of luteinizing hormone, follicle-stimulating hormone, and epidermal growth factor on expression and kinase activity of cyclin-dependent kinase 5 in Leydig TM3 and Sertoli TM4 cell lines
luteinizing hormone follicle-stimulating hormone growth factor kinase activity cyclin-dependent kinase 5
2008/12/25
We examined the effects of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and epidermal growth factor (EGF) on the expression and kinase activity of cyclin-dependent kinase 5 (Cdk5)...
Hepatocyte Growth Factor-Modulated Rat Leydig Cell Functions
c-met HGF testosterone caspase-3 apoptosis testis
2008/12/24
Hepatocyte growth factor (HGF) regulates many cellular functions acting through c-Met, its specific tyrosine kinase receptor. We previously reported that in prepuberal rats HGF is secreted by the pe...
Functional Role of Hepatocyte Growth Factor Receptor During Sperm Maturation
C-met spermatozoa rat testis epididymis
2008/12/16
Mammalian spermatozoa acquire motility and fertilizing capacity during their transit through the epididymis. Hepatocyte growth factor (HGF) is a pleiotropic cytokine with potent motogenic capacities t...
Absence of Association Between Transforming Growth Factor–β1 Promoter Polymorphisms and Hypodontia
TGF-β1 Hypodontia Tooth agenesis
2008/12/15
Hypodontia, the congenital absence of one or a few teeth, is one of the most common alterations of the human dentition. The most common permanent missing teeth are the third molars, second premola...
Neutralizing Effects of an Anti-Vascular Endothelial Growth Factor Antibody on Tooth Movement
VEGF Anti-VEGF polyclonal antibody Osteoclast Bone remodeling Experimental tooth movement
2008/11/20
Our recent studies demonstrated that local administration of recombinant human vascular endothelial growth factor (rhVEGF) during experimental tooth movement enhanced the number of osteoclasts and the...
Platelet-derived Growth Factor Enhances Proliferation and Matrix Synthesis of Temporomandibular Joint Disc–derived Cells
Temporomandibular joint disc Tissue engineering Platelet-derived growth factor
2008/11/19
Platelet-derived growth factor (PDGF) is an essential signaling molecule for wound healing and tissue repair. This study was aimed at evaluating the effect of PDGF on the proliferation of temporoman...
Dental and Craniofacial Characteristics in a Patient with Leprechaunism Treated with Insulin-Like Growth Factor-I
Enlarged teeth Macroglossia Leprechaunism IGF-I Craniofacial morphology
2008/11/6
Leprechaunism is an autosomal recessive disease characterized by elfin-like faces, loss of glucose homeostasis, and severe insulin resistance. This disease is caused by inherited defects of the insuli...
Epidermal Growth Factor in Liposomes May Enhance Osteoclast Recruitment during Tooth Movement in Rats
EGF Liposome Osteoclasts Tooth movement Orthodontic movement
2008/11/6
Objective: To evaluate the effects of local administration of epidermal growth factor (EGF) located within liposomes on recruitment of osteoclasts during mechanical force in rats.Materials and Methods...
Age-related Differences in Expression of Vascular Endothelial Growth Factor by Periodontal Ligament Cells In Vitro
Aging VEGF Periodontal ligament In vitro
2010/1/20
The purpose of this study was to evaluate age-related differences in expression of vascular endothelial growth factor (VEGF) by periodontal ligament (PDL) cells. PDL cells were obtained from Wistar ma...
Age-related Differences in Expression of Vascular Endothelial Growth Factor by Periodontal Ligament Cells In Vitro
Aging VEGF Periodontal ligament
2010/12/1
The purpose of this study was to evaluate age-related differences in expression of vascular endothelial growth factor (VEGF) by periodontal ligament (PDL) cells. PDL cells were obtained from Wistar ma...