搜索结果: 46-55 共查到“医学 Alzheimer”相关记录55条 . 查询时间(0.037 秒)
Alzheimer型痴呆的CT与MRI研究
MRI 痴呆
2008/3/17
目的 验证海马萎缩在Alzheimer型痴呆(DAT)中作为一种预测标志的价值,为临床提供辅助诊断方法。材料与方法 选30名受检者全部通过简易精神状态检查( mini-mental state examination,MMSE),CT扫描观察海马周围裂的变化,并测量海马内侧的脑脊液池(HCSF),即测量环池内侧边到颞叶内侧边之间的距离。选其中13名行MRI扫描测量海马结构(HF)体积。结果 在正常...
组织蛋白酶D基因C224T多态与散发阿尔茨海默氏病的关联研究The C224T Polymorphism in the Cathepsin D Gene is not Associated with Sporadic Alzheimer’s Disease in Chinese
阿尔兹海默氏病 组织蛋白酶基因 多态性 限制性片段长度
2008/1/10
摘要
组织蛋白酶D(Cathepsin D)是一种细胞核内体/溶酶体内的门冬酰胺蛋白酶。它有可能通过剪切淀粉样前体蛋白参与阿尔茨海默氏病(Alzheimer’s disease, AD)相关的神经退化。在以德国人为对象中的研究显示组织蛋白酶D基因(CTSD)C224T多态与AD发病风险紧密相关。然而,此结果未能在另一些群体中得到重复。为此,我们通过聚合酶链反应-限制性片段长度多态性方法分析了C...
摘要阿尔茨海默类痴呆(AD)是老年痴呆中最常见的一种,它以渐进性的神经功能退化并伴随着整体认知能力的下降为特征。早发性AD主要是由β-淀粉样前体蛋白(APP)基因和早老素基因突变引起,而与晚发性AD发病明显相关的只有载脂蛋白E-ε4 ( APOE-ε4)等位基因。但是APOE-ε4等位基因对AD发病既非充分又非必要,而且只能解释少于50%的AD的遗传变异。所以有必要进一步寻找与AD的关联基因。
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Alzheimer病患者MLL3基因表达量的研究
Alzheimer病 MLL3基因 表达量 关联
2007/12/19
目的 本工作旨在从MLL3(mixed-lineage leukemia 3, MLL3)基因入手,尝试探讨Alzheimer病(Alzheimer’s disease,AD)与该基因表达量的相关关系。 方法 工作在45例AD患者、25例血管性痴呆(vascular dementia,VD)患者和60名年龄性别相匹配的对照中进行,在新鲜外周血样本中抽提总RNA,反转录成cDNA,基因表达量的检测在...
Omega-3 Fatty Acid Trial to Study Effect on Progression of Alzheimer’s
Alzheimer’s disease Omega-3 Fatty Acid
2007/5/29
A Century Later, New Research Brings Initial Find of Alois Alzheimer to Fore Once Again
Alzheimer’s disease blood
2007/1/24
NEUROPATHOLOGICAL CHANGES IN THE PDAPP TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE
Alzheimer's disease immunohistochemistry medal septal nucleus diagonal band of Broca
2010/2/3
Alzheimer’s disease (AD) is a uniquely human disorder. Although the pathogenesis of AD is not fully understood, growing evidence indicates that the deposition of beta-amyloid (Aβ) and the local reacti...
Oxidative stress and Alzheimer disease1
Alzheimer disease free radicals antioxidants, b-amyloid oxidative stress metal humans
2016/6/3
Research in the field of molecular biology has
helped to provide a better understanding of both the cascade of
biochemical events that occurs with Alzheimer disease (AD) and
the heterogeneous natur...
Alzheimer disease: protective factors
Alzheimer disease nutrition estrogen homocysteine, nonsteroidal antiinflammatory drugs
2016/6/3
Approximately 6–8% of all persons aged >65 y
have Alzheimer disease and the prevalence of the disease is
increasing. Any intervention strategy aimed at decreasing risks or
delaying the onset of the...
Energy expenditure, energy intake, and weight loss in Alzheimer disease
Alzheimer disease energy expenditure, weight loss body composition metabolic rate cachexia dementia
2016/6/3
Alzheimer disease is one of the leading causes
of death among older individuals. Unexplained weight loss and
cachexia are frequent clinical findings in patients with Alzheimer
disease. Thus, it has...