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Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity
5-a-Reductase androgen receptor micropenis
2009/2/11
Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron-type dwarfism suggests that factors such as GH or insulin-like growth factor 1 (IGF-1) might in addition to ...
Binding of methyltrienolone to androgen receptors in human skin fibroblasts is enhanced by insulin
R1881 cycloheximide actinomycin D DNA protein
2009/2/10
Previous reports have suggested a relationship between hyperinsulinemia and increased androgen secretion leading to female virilization, but no report has been made of the effects of insulin on an...
Effects of insulin-like growth factor-I on androgen production by highly purified pubertal and adult rat Leydig cells
Somatomedin-C development steroidogenesis
2009/2/10
Leydig cells were isolated and purified from adult and midpubertal rats to study the effects of insulin-like growth factor-I (IGF-I) on steroidogenesis. Androgen production, as measured in Leydig ce...
Adipose compartmentalization and insulin resistance among obese HIV-infected women：the role of intermuscular adipose tissue
Adipose compartmentalization insulin resistance obese HIV-infected women intermuscular adipose tissue
2008/12/25
Changes in adipose tissue volume and distribution have been linked to the development of insulin resistance and the metabolic syndrome in non-HIV-infected individuals. These changes may occur in c...
Insulin-Dependent Diabetes Affects Testicular Function by FSH- and LH-Linked Mechanisms
Testes follicle-stimulating hormone luteinizing hormone
2008/12/22
A study was conducted to form a unified hypothesis regarding the gonadotropin-related mechanisms that underlie alterations in the male reproductive system in individuals with diabetes. Streptozotoci...
Treatment for 2 mo with n–3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study
Adiposity fish oil type 2 diabetes women adipocyte size PAI-1 atherogenic index adipose tissue inflammation-related genes
2008/12/17
Background: Information is lacking on the potential effect of n–3 polyunsaturated fatty acids (PUFAs) on the adipose tissue of patients with type 2 diabetes.Objective: We evaluated whether n–3 PUFAs h...
Altered postprandial glucose, insulin, leptin, and ghrelin in liver cirrhosis: correlations with energy intake and resting energy expenditure
Glucose insulin leptin ghrelin insulin resistance energy intake
2008/12/12
Background:Liver cirrhosis is associated with reduced energy intake and increased resting energy expenditure. Objective:We aimed to investigate the possible role of glucose, insulin, leptin, and ghrel...
Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women1,2,3
Dietary patterns metabolic syndrome insulin resistance factor analysis women
2008/12/12
Background: Although individual foods and nutrients have been associated with the metabolic syndrome, whether dietary patterns identified by factor analysis are also associated with this syndrome is n...
Many studies in the medical literature have indicated that the consumption of chili-containing meals increases energy expenditure and fat oxidation. Moving toward this direction, a new study regarding...
Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise1,2,3
Insulin resistance skeletal muscle intramyocellular triacylglycerol dietary fat exercise
2008/12/10
Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations are associated with diminished insulin sensitivity in skeletal muscle. This lipid accumulation is most likely ...
Resistance training and dietary protein: effects on glucose tolerance and contents of skeletal muscle insulin signaling proteins in older persons1,2,3
Protein diet resistance training skeletal muscle insulin signaling elderly
2008/12/9
Background:Resistance training (RT) and dietary protein independently influence indexes of whole-body glucose control, though their synergistic effects have not yet been documented.Objective:This stud...
Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study1,2,3
Atherosclerosis cereals diet ethnic groups cohort studies Doppler ultrasound
2008/12/9
Background: Whole-grain intake has been shown to be inversely associated with cardiovascular events, but an association with atherosclerosis is less well established. Objective: We sought to evaluate ...
Dental and Craniofacial Characteristics in a Patient with Leprechaunism Treated with Insulin-Like Growth Factor-I
Enlarged teeth Macroglossia Leprechaunism IGF-I Craniofacial morphology
2008/11/6
Leprechaunism is an autosomal recessive disease characterized by elfin-like faces, loss of glucose homeostasis, and severe insulin resistance. This disease is caused by inherited defects of the insuli...
Acute effect of meal glycemic index and glycemic load on blood glucose and insulin responses in humans
blood glucose glycemic load glycemic index
2008/4/23
Foods with contrasting glycemic index when incorporated into a meal, are able to differentially modify glycemia and insulinemia. However, little is known about whether this is dependent on the size of...
Distribution of Serum Total Homocysteine and Its Association with Diabetes and Cardiovascular Risk Factors of the Insulin Resistance Syndrome in Mexican American Men: The Third National Health and Nutrition Examination Survey
Association Homocysteine
2008/4/23
Few data have been published on the association of variables of the insulin resistance syndrome and serum total homocysteine (tHcy), a putative risk factor for cardiovascular morbidity, in representat...