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Expression, action, and regulation of transforming growth factor alpha and epidermal growth factor receptor during embryonic and perinatal rat testis development
FSH gametogenesis mesenchymal-epithelial Sertoli
2008/12/29
The objective of the current study was to extend previous observations and examine the expression pattern and effects of transforming growth factor alpha (TGFalpha) and epidermal growth factor recep...
Immunobiology of a synthetic luteinizing hormone receptor peptide 21-41
Testicular function spermatogenesis receptor antibodies
2008/12/29
Immunization of adult male rabbits with a synthetic luteinizing hormone-receptor peptide (LH-RP; representing amino-acids 21-41 of the extracellular domain of the rat LH receptor) resulted in prod...
CAG repeat length analysis and mutation screening of the androgen receptor gene in Japanese men with idiopathic azoospermia
Male infertility Kennedy disease sperm production
2008/12/29
Because androgens are required for normal spermatogenesis, we are investigating abnormalities in the androgen receptor as a possible cause of impaired spermatogenesis in patients with idiopathic mal...
Immortalized testis cell lines from estrogen receptor（ER）alpha knock-out and wild-type mice expressing functional ERalpha or ERbeta
Immortalization HPV E6/E7 in vitro models
2008/12/29
The surprising findings that male mice lacking the estrogen receptor (ER) alpha (alphaERKO) have atrophic testis and are infertile proved that ERalpha is involved in normal testicular function. To o...
E2F and GATA-1 are required for the Sertoli cell-specific promoter activity of the follicle-stimulating hormone receptor gene
Transcription factor testis gonadotropin
2008/12/29
The follicle-stimulating hormone receptor (FSHR) gene is expressed in Sertoli cells in males and in granulosa cells in females. Cis-acting sequences and associated binding factors responsible for ...
Androgen receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate cancer xenograft
Androgen receptor regulation G1 cyclin cyclin-dependent kinase CWR22 huma prostate cancer
2008/12/29
Human prostate cancer is initially dependent on androgens for growth, and androgen-dependent cells undergo apoptosis after castration. However, a subset of androgen-responsive cells survives and event...
Larger trinucleotide repeat size in the androgen receptor gene of infertile men with extremely severe oligozoospermia
Larger trinucleotide repeat size androgen receptor gene infertile men
2008/12/26
Androgens are significant regulators of human spermatogenesis. Their action is mediated through the androgen receptor (AR), which binds to the androgen responsive element on DNA and regulates gene tra...
Ala12 variant of the peroxisome proliferator-activated receptor- gene（PPARG）is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction
Cardiovascular disease peroxisome proliferatoractivated receptor- PPARG polyunsaturated fatty acids
2008/12/25
Background: Intake of polyunsaturated fat is protective against the development of coronary heart disease. Less is known about the genetic variation modulating this association. The Ala12 allele of th...
Targeted disruption of the cation-dependent or cation-independent mannose 6-phosphate receptor does not decrease the content of acid glycosidases in the acrosome
cation-dependent cation-independent mannose 6-phosphate acid glycosidases acrosome
2008/12/25
The acrosome is a unique organelle containing acid hydrolases common to lysosomes as well as unique enzymes. Its ultimate exocytosis, as well as the absence of several lysosomal markers, has led to ...
Presence of NMDA receptor subunits in the male lower urogenital tract
NMDA receptor subunits male lower urogenital tract
2008/12/25
Some sexual responses in the male rat, specifically penile erection, are controlled by neural circuits in the brain and spine that are stimulated by the binding of excitatory amino acids (EAAs) to...
Identification and regulation of receptor tyrosine kinases Rse and Mer and their ligand Gas6 in testicular somatic cells
Identification regulation receptor tyrosine kinases Mer Gas6 testicular somatic cells
2008/12/25
Receptor tyrosine kinases act to convey extracellular signals to intracellular signaling pathways and ultimately control cell proliferation and differentiation. Rse, Axl, and Mer belong to a newly i...
Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice
Morphologic changes efferent ductules epididymis estrogen receptor-alpha
2008/12/25
Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the ...
The mouse sperm glycine receptor/chloride channel：cellular localization and involvement in the acrosome reaction initiated by glycine
mouse sperm glycine receptor/chloride channel cellular localization involvement glycine
2008/12/25
Previously, we reported that glycine initiates the in vitro acrosome reaction (AR) of porcine and human sperm by a mechanism that includes the glycine receptor/Cl- channel (GlyR) and that this recep...
Androgen receptor gene polymorphism and prostate zonal volumes in Australian and Chinese men
Androgen receptor gene polymorphism prostate zonal volumes Australian Chinese men
2008/12/25
Prostate diseases are age and androgen dependent. The evolution of clinically overt pathology requires decades of exposure to adult male levels of circulating testosterone, but the precise relations...
Biphasic Effect of Androgens on Prostate Cancer Cells and Its Correlation With Androgen Receptor Coactivator Dopa Decarboxylase
Neuroendocrine differentiation methyltoenolone cDNA microarray
2008/12/24
The aim of this study was to explore the mechanism underlying the dual effect of androgen on prostate cancer cells and further explore its correlation with dopa decarboxylase (DDC), an androgen r...