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Conversion of the Bifunctional 8-oxoguanine/β-δ AP DNA Repair Activities of Drosophila Ribosomal Protein S3 into the Human S3 Monofunctional β- elimination Catalyst Through a Single Amino Acid Change
DNA repair drosophila ribosomal protein s3
2014/12/12
The Drosophila S3 ribosomal protein has important roles in both protein translation and DNA repair. In regards to the latter activity, it has been shown that S3 contains vigorous N-glycosylase activit...
A novel fluorometric oligonucleotide assay to measure O 6-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase
APE1/Ref-1 DNA repair status
2014/12/12
DNA repair status plays a major role in mutagenesis, carcinogenesis and resistance to genotoxic agents. Because DNA repair processes involve multiple enzymatic steps, understanding cellular DNA repair...
Conditional Targeting of the DNA Repair Enzyme hOGG1 into Mitochondria
DNA repair mitochondria
2014/12/12
Oxidative damage to mitochondrial DNA (mtDNA) has been suggested to be a key factor in the etiologies of many diseases and in the normal process of aging. Although the presence of a repair system to r...
Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation
Ape1 inhibitor base excision repair biomarkers
2014/12/12
There has been a recent upsurge in the development of small-molecule inhibitors specific to DNA repair proteins or proteins peripherally involved in base excision repair and the DNA damage response. T...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has a pleiotropic role in control...
Role of inflammation in right ventricular damage and repair following experimental pulmonary embolism in rats
healing inflammation macrophages neutrophils pulmonary embolism right ventricle
2014/11/28
Right ventricular (RV) dysfunction is associated with poor clinical outcome following pulmonary embolism (PE). Previous studies in our laboratory show that influx of neutrophils contributes to acute R...
New concepts in Aortic Arch Repair. Are we Heading in the Right Way?
Department of Cardiovascular Surgery,Hospital Clinico,University of Barcelona,Barcelona,Spain
2010/4/6
The standard approach for repair of type A aortic dissection includes repair or replacement of the aortic valve, the ascending aorta and the arch, alone or in combination with direct vision under hypo...
Complex tibial plateau fracture repair with hybrid external fixator:report of 15 cases
Tibial plateau hybrid external fixator ORIF
2009/12/18
Background: Proper knee function is essential for daily activity. Since almost all complex tibial plateau fractures involve soft tissue compromise, there is some controversy as to the best treatment m...
KETAMINE HAS NO PRE-EMPTIVE ANALGESIC EFFECT IN CHILDREN UNDERGOING INGUINAL HERNIA REPAIR
Preemptive analgesia ketamine children inguinal hernia
2009/12/15
Previous studies have suggested that ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, provides a pre-emptive analgesic effect and pre-emptive analgesia improves postoperative pain managem...
RESIDUAL DEFECTS AFTER SURGICAL REPAIR OF VENTRICULAR SEPTAL DEFECTS IN CHILDREN:INCIDENCE,RISK FACTORS AND FOLLOW-UP
Ventricular septal defect echocardiography children congenital heart diseases corrective surgery
2009/12/14
Residual ventricular septal defects (VSD) are major complications after cardiac surgery. We studied the incidence of this complication, risk factors for its occurrence and short-term follow-up in 179 ...
SUTURE NON-SUTSRE CIRCUMFERENTIAL REPAIR OF CAROTID ARTERY
SUTURE NON-SUTSRE CIRCUMFERENTIAL REPAIR CAROTID ARTERY
2009/12/3
plastic adhesives, normal butyl cyanoacrylate monomer, isobutyl cyanoacrylate monomer and methyl 2 _ cyaooacrylate monomer, have been utilized in a comparative study with 5-{) silk suture in the repai...
The Healing Effect of Vitreous Body on Repair of Cartilage Defects of Knee Joint in Dog as an Animal Model
Vitreous body Healing Cartilage defect Knee Joint Dog
2015/9/18
Background: To investigate the healing effects of vitreous body in repair of cartilage defects of the knee joint in dog as an animal model.
Myeloshisis is defined as an open neural tube defect involving malformation of the vertebral arches, absence of meninges and structural or functional spinal cord abnormalities. Neural placode is locat...
A Simple Surgical Technique for Repair of Iridodialysis
Iridodialysis simple surgical repair
2009/5/21
A simple surgical technique is described for repair of iridodialysis and a traumatic iridodialysis case is presented. In this technique, a 10-0 polypropylene suture is used for repair. The knot is lef...