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2021年12月7日，Journal of Clinical Investigation杂志在线发表了军事科学院军事医学研究院、国家蛋白质科学中心（凤凰中心）唐丽/贺福初团队联合上海交通大学医学院上海市免疫学研究所王静团队的合作成果 “ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of ...
浙江大学遗传学研究所管敏鑫教授课题组在The Journal of Clinical Investigation上发表发表Leber遗传性视神经病变最新研究进展（图）
浙江大学遗传学研究所 管敏鑫 教授 Leber 遗传性 视神经病变
2020/6/16
2020年6月9日，浙江大学遗传学研究所管敏鑫教授团队在国际权威期刊《临床研究杂志》（The Journal of Clinical Investigation）在线发表了X连锁核修饰基因突变引发Leber’s遗传性视神经病变（LHON）的最新研究成果。经过八年努力，首次发现了X连锁核修饰基因PRICKLE3突变与线粒体基因突变协同作用引发LHON，破解了LHON男性好发这一三十年未解之谜。这是线...
浙江大学生命科学研究院靳津实验室在Journal of Clinical Investigation发文阐明USP16调控成熟T细胞活化的关键作用与机制（图）
浙江大学生命科学研究院 靳津 USP16 成熟T细胞活化
2019/10/9
2019年5月28号，靳津实验室在Journal of Clinical Investigation（JCI）发表题为“USP16-mediated deubiquitination of calcineurin A controls peripheral T cell maintenance”的研究论文，揭示了USP16调控成熟T细胞的活化的关键作用与机制，并发现USP16可作为T细胞介导的自身...
Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
breast cancer EPIC antioxidants carotenoids plasma
2018/11/27
Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity.
Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
Phosphatase of Regenerating Liver PTEN Mouse Models
2015/5/25
The addition and removal of phosphate groups is a key regulatory mechanism for many cellular processes. The balance between phosphorylation and dephosphorylation is delicate and must be maintained in ...
Investigation of electron transport proteins in the Geobacteraceae
Biological iron electron transfer mechanism nitrate the cell outside the cell
2015/1/28
Biological Fe(III) reduction is an environmentally significant process, but the mechanisms of electron transfer to Fe(III) are poorly understood. While soluble electron acceptors like oxygen and nitra...
Investigation of Fe(III) Reduction in Geobacter Sulfurreducens Characterization of Outer Surface Associated Electron Transfer Components
cytochrome c Fe(III) reduction Geobacter sulfurreducens
2015/1/28
Outer membrane cytochromes OmcB and OmcS of Geobacter sulfurreducens are two important components of the respiratory chain for extracellular Fe(III) reduction. OmcS is a loosely bound cell surface pro...
Investigation of a sulfur-utilizing perchlorate-reducing bacterial consortium
bacterial consortium Beta-Proteobacteria bioreactor bioremediation perchlorate sulfur
2015/1/28
We present research investigating how, with in depth knowledge of the community, microbial communities may be harnessed for bioremediation of hazardous water contaminants. We focused on the bacterial ...
Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)
cohort study epidemiology obesity physical activity exercise mortality population attributable fraction
2018/12/24
Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity c...
Investigation of Differential Vector Competence of Bartonella quintana in Human Head and Body Lice
lice bartonella vector
2014/12/12
Human head and body lice are obligatory hematophagous ectoparasites that belong to a single species Pediculus humanus. Only body lice, however, are vectors of the infections gram-negative bacteria Bar...
Connecting Motors and Membranes: A Quantitative Investigation of Dynein Pathway Components and in vitro Characterization of the NUM1 Coiled Coil Domain
Connecting Motors and Membranes Dynein Pathway Components vitro Characterization NUM1 Coiled Coil Domain
2014/12/12
In the budding yeast, Saccharomyces Cerevisiae, dynein, a minus-end directed motor, is involved in nuclear migration and proper orientation of the mitotic spindle during mitosis. Our lab has developed...
The HFD of Cse4p is sufficient for a functional centromere specific nucleosome: An investigation into kinetochore formation on cen DNA
Centromere chromosomes cell division protein chromosome axis of fiber
2014/12/11
Centromeres are the site on a chromosome that allows for proper chromosome segregation during cell division. The kinetochore, a DNA-protein complex that forms at the centromere, attaches the chromosom...
Regulation and Action of Skp2 and Rhoa in Cell and Tumor Models: Investigation into the Molecular Mechanisms Responsible for the Aggressive Phenotype of Triplenegative Breast Cancer
Basal-Like Breast Cancer Cell Cycle p27 proliferation SKP2 Triple-Negative Breast Cancer
2014/12/10
Breast cancer tops the list of new cancer cases and is predicted to be the second leading cause of cancer deaths in women in 2012. The primary objective of the present study was to provide insights in...
Investigation of MC1R SNPs and Their Relationships with Plumage Colors in Korean Native Chicken
Korean Native Chicken MC1R Plumage Color SNPs
2016/5/11
The melanocortin 1 receptor (MC1R) gene is related to the plumage color variations in chicken. Initially, the MC1R gene from 30 individuals was sequenced and nine polymorphisms were obtained. Of these...
Investigation of Forces and Stresses Acting on a Shoulder-Hand System Considering Strains in Muscles
Biomechanical modeling Humerus bone Stresses on shoulder-hand system
2009/10/9
A model is proposed to investigate the forces and stresses acting on bones in a shoulder-hand system due to straining of muscles during daily physical activities. This model is proposed as a truss sys...