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Imagine a ball thrown in the air: It curves up, then down, tracing an arc to a point on the ground some distance away. The path of the ball can be described with a simple mathematical equation, and if...
Perturbations of the Distal Heme Pocket in Human Myoglobin Mutants Probed by Infrared Spectroscopy of Bound CO:Correlation with Ligand Binding Kinetics
Distal Heme Pocket Human Myoglobin Mutants Probed Infrared Spectroscopy Bound CO:Correlation Ligand Binding Kinetics
2016/5/23
The infrared spectra of CO bound to human myoglobin and myoglobin mutants at positions His-64, Val-68, Asp-60, and Lys-45 on the distal side have been measured between 100 and 300 K. Large differences...
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level
fatty liver gene expression liver injury metabolomics transaminases
2018/11/27
Background: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental cha...
The integrated stress response directs cell fate decisions in response to perturbations in protein homeostasis
diabetes cancer
2015/5/25
Disruptions of the endoplasmic reticulum (ER) cause perturbations in protein folding and result in a cellular condition known as ER stress. ER stress and the accumulation of unfolded protein activate ...
Phenotypic robustness can increase phenotypic variability after non-genetic perturbations in gene regulatory circuits
Phenotypic robustness increase phenotypic variability non-genetic perturbations gene regulatory circuits
2010/11/15
Non-genetic perturbations, such as environmental change or developmental noise, can induce novel phenotypes. If an induced phenotype confers a fitness advantage, selection may promote its genetic sta...