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Tudor Domain Containing Protein TDRD12 Expresses at the Acrosome of Spermatids in Mouse Testis
Tdrd12 Tudor Spermatogenesis Acrosome Spermatid Testis
2016/7/27
Tdrd12 is one of tudor domain containing (Tdrd) family members. However, the expression pattern of Tdrd12 has not been well studied. To compare the expression levels of Tdrd12 in various tissues, real...
Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1: A NOVEL PARTICIPANT IN GLYCOGEN METABOLISM
autophagy GABARAPL1 AIM/LIR
2015/5/25
Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types. The breakdown of glycogen by hormonally regulated degradation involving the ...
Connecting Motors and Membranes: A Quantitative Investigation of Dynein Pathway Components and in vitro Characterization of the NUM1 Coiled Coil Domain
Connecting Motors and Membranes Dynein Pathway Components vitro Characterization NUM1 Coiled Coil Domain
2014/12/12
In the budding yeast, Saccharomyces Cerevisiae, dynein, a minus-end directed motor, is involved in nuclear migration and proper orientation of the mitotic spindle during mitosis. Our lab has developed...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Components of a Protein Machine: Allosteric Domain Assembly and a Disordered C-terminus Enable the Chaperone Functions of Hsp70
Allostery DnaK Hsp70 Intrinsic disorder Molecular chaperone Protein folding
2014/12/10
Hsp70 molecular chaperones protect proteins from aggregation, assist in their native structure formation, and regulate stress responses in the cell. A mechanistic understanding of Hsp70 function will ...
Feronia: A Malectin-Like Domain-Containing Receptor Kinase in Arabidopsis Thalina
Pure sciences Biological sciences Malectin-like Domain-containing Receptor kinases Arabidopsis thaliana Polarized cell growth Pollen tube - Pistil interactions Sugar signaling
2014/12/10
RAC/ROPs are a unique group of RAS-related monomeric G proteins (small G proteins) that constitute the sole family of Rho GTPases in plants. RAC/ROPs, like their counterpart Rho GTPases from mammalian...
Metagenome Analysis of Protein Domain Collocation within Cellulase Genes of Goat Rumen Microbes
Goat Rumen Shot-gun Sequencing Metagenome Protein Domain
2016/5/12
In this study, protein domains with cellulase activity in goat rumen microbes were investigated using metagenomic and bioinformatic analyses. After the complete genome of goat rumen microbes was obtai...
Phosphorylation Status of RNA Polymerase II Carboxyl-terminal Domain in Porcine Oocytes and Early Embryos
RNA Polymerase II Porcine Oocyte Embryos α-Amanitin
2016/5/10
Fertilization of the oocyte commences embryogenesis during which maternally inherited mRNAs are degraded and the embryonic genome is activated. Transcription of embryonic mRNA is initiated by embryoni...
Characteristic spectral features of the polarized fluorescence of human breast cancer in the wavelet domain
Florescence Spectroscopy Wavelet Transform Biomedical Optics Breast Cancer
2012/5/17
Wavelet transform of polarized fluorescence spectra of human breast tissues is found to localize spectral features that can reliably differentiate normal and malignant tissue types. The intensity diff...
Information theoretic interpretation of frequency domain connectivity measures
Information theoretic interpretation frequency domain connectivity measures
2011/1/5
To provide adequate multivariate measures of information flow between neural structures, modified expressions of Partial Directed Coherence (PDC) and Directed Transfer Function (DTF), two popular mult...
Molecular modeling of the HAMP domain of sensory rhodopsin II transducer from Natronomonas pharaonis
Molecular dynamics simulation Coiled-coil Signal transduction Homology model Af1503
2010/12/2
The halobacterial transducer of sensory rhodopsin II (HtrII) is a photosignal transducer associated with phototaxis in extreme halophiles. The HAMP domain, a linker domain in HtrII, is considered to p...
小鼠canstatin及其N端片段在大肠杆菌BL21中的表达Expression of Mouse canstatin and its N-domain in E.coli BL21
canstatin 血管生成抑制素 RT-PCR cDNA克隆
2008/1/20
摘要 以小鼠肝脏组织总RNA为模板，通过RT-PCR扩增小鼠canstatin及其N端片段基因，克隆到pMD18-T载体中并进行序列分析。将小鼠canstatin及其N端片段基因定向克隆于原核表达载体pET30a(+)中,分别构建表达质粒pET/Can和pET/Can-N, 转化大肠杆菌BL21(DE3), IPTG诱导表达。结果表明: 小鼠canstatin的cDNA长度为684bp，编码227...
专著信息
书名
Letter to the Editor:1H, 13C and 15N resonance assignments and secondary strucutre of ADR6 DNA-binding Domain
语种
英文
撰写或编译
作者
Xiaoming Tu,Jihui Wu,Yingqi Xu and Yunyu Shi
第一作者单位
出版社
J. of Biomo...
专著信息
书名
Shao-man Yin, Man-Sun Sy, Po Tien*. An engineered PrPsc-like molecule from the chimera of mammalian prion protein and yeast prion-inducing domain. Acta Biochimica et Biophyica Sinica., 36 (2):...