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Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Modulation of epidermal growth factor receptor function by mutations within the actin -binding domain
Genes actin internalization growth factors tyrosine phenylalanine glutamic acid phenylalanine residues
2014/12/11
The generation of site-directed mutants within the actin binding domain of the EGF receptor modulates receptor function in internalization and ligand binding. In addition, truncation of the EGFr at re...
Components of a Protein Machine: Allosteric Domain Assembly and a Disordered C-terminus Enable the Chaperone Functions of Hsp70
Allostery DnaK Hsp70 Intrinsic disorder Molecular chaperone Protein folding
2014/12/10
Hsp70 molecular chaperones protect proteins from aggregation, assist in their native structure formation, and regulate stress responses in the cell. A mechanistic understanding of Hsp70 function will ...
Feronia: A Malectin-Like Domain-Containing Receptor Kinase in Arabidopsis Thalina
Pure sciences Biological sciences Malectin-like Domain-containing Receptor kinases Arabidopsis thaliana Polarized cell growth Pollen tube - Pistil interactions Sugar signaling
2014/12/10
RAC/ROPs are a unique group of RAS-related monomeric G proteins (small G proteins) that constitute the sole family of Rho GTPases in plants. RAC/ROPs, like their counterpart Rho GTPases from mammalian...
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书名
Shao-man Yin, Man-Sun Sy, Po Tien*. An engineered PrPsc-like molecule from the chimera of mammalian prion protein and yeast prion-inducing domain. Acta Biochimica et Biophyica Sinica., 36 (2):...
期刊信息
篇名
Interactions of Stathmin-like 2 protein with the APP intracellular domain.
语种
英文
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撰写
作者
Li,Z.,Wang,W.,Zhou,F.,Gao,X.,Peng,G.,Xu,H.,and Chen,Y-G#
第一作者单位
刊物名称
Tsinghua Science and Technolog...
期刊信息
篇名
CP1 Domain in Escherichia coli Leucyl-tRNA Synthetase is Crucial for its Editing Function
语种
英文
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撰写
作者
Jian-Feng Chen,Ni-Ni Guo,Tong Li,En-Duo Wang(通讯作者)and Ying-Lai Wang
第一作者单位
中科院上海生化所分...