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浙江大学生命科学学院陈才勇团队在Blood上发文揭示红细胞铁代谢重要调控机制（图）
陈才勇 红细胞铁代谢 单核苷酸
2022/10/12
红细胞是人体数量最多的一类细胞，其在成熟过程中需要吸收大量铁离子以用于合成血红素和血红蛋白。转铁蛋白（Tf）循环是红细胞以及其它很多类型细胞吸收铁离子的主要通路。在Tf循环中，细胞膜上的转铁蛋白受体（Tfrc）结合带铁的Tf后通过内吞作用进入细胞，释放铁离子，然后Tf-Tfrc复合体通过再循环内体回到细胞膜，因此该循环涉及Tfrc在细胞膜、初级内体和再循环内体之间的反复循环。为了快速吸收铁离子，红...
Harmonization of blood-based indicators of iron status: making the hard work matter
assay bias clinical bioindicator harmonization imprecision iron status reference material reference method standardization
2018/11/21
Blood-based indicators that are used in the assessment of iron status are assumed to be accurate. In practice, inaccuracies in these measurements exist and stem from bias and variability. For example,...
Changes in leukocyte counts, lymphocyte subpopulations and the mRNA expression of selected cytokines in the peripheral blood of dogs with atopic dermatitis
chronic inflammation B-lymphocytes double-positive lymphocytes stress
2015/11/26
Canine atopic dermatitis (CAD) is a chronic allergic disease characterised by genetic predisposition.
The exact pathogenesis of the disease is still not fully understood. Blood parameters, lymphocyt...
A sportomics strategy to analyze the ability of arginine to modulate both ammonia and lymphocyte levels in blood after high-intensity exercise
White blood cells Granulocyte Amino acids
2015/7/23
Exercise is an excellent tool to study the interactions between metabolic stress and the immune
system. Specifically, high-intensity exercises both produce transient hyperammonemia and influence the ...
2015年6月18日，由北京大学人民医院黄晓军教授领衔的前瞻、多中心临床试验“急性髓系白血病第一次缓解期单倍体与同胞全合造血干细胞移植疗效对比” 研究成果在国际血液学领域的顶级学术期刊Blood（IF=10.452）正式发表（Blood. 2015;125(25):3956-62）。该项研究发现，对于第一次缓解期的中高危急性髓系白血病，亲缘单倍体移植与同胞相合移植等同疗效。
Derivation of endothelial colony forming cells from human cord blood and embryonic stem cells
Embryonic Stem Cells Directed Differentiation Human Umbilical Cord Blood
2015/5/25
Endothelial Colony Forming Cells (ECFCs) are highly proliferative endothelial progenitor cells with clonal proliferative potential and in vivo vessel forming ability. While endothelial cells have been...