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浙江大学转化医学研究院吕志民团队Molecular Cell发文揭示氧气调节线粒体生物合成新机制(图)
浙江大学转化医学研究院 吕志民 Molecular Cell 氧气调节 线粒体生物 新机制
2019/12/3
动物细胞感知和适应氧气的变化是生命活动的重要基础。2019年诺贝尔生理学或医学家授予了William G. Kaelin Jr.、Peter J. Ratcliffe和Gregg L. Semenza,以表彰他们在揭示细胞感知和适应氧气供应机制方面做出的杰出贡献。线粒体是细胞内最主要的耗氧细胞器,也是细胞代谢的核心场所,为细胞提供充足的能量和物质。实体肿瘤由于生长迅速,其核心区域常处于低氧状态。在...
Obstacles and Circumvention Strategies for Hematopoietic Stem Cell Transduction by Recombinant Adeno-associated Virus Vectors
gene therapy hematopoietic stem cells sickle cell disease
2015/5/21
High-efficiency transduction of hematopoietic stem cells (HSCs) by recombinant adeno-associated virus serotype 2 (AAV2) vectors is limited by (i) inadequate expression of cellular receptor/co-receptor...
Multiple, Brief Coronary Occlusions During Early Reperfusion Protect Rabbit Hearts by Targeting Cell Signaling Pathways
cells Reperfusion Multiple
2014/3/31
All procedures were approved by the Institutional Animal
Care and Use Committee and were in accordance with
recommendations published in the Guide for the Care and
Use of Laboratory Animals(Nationa...