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南京农业大学农学院《Nature Communications》发表万建民院士团队“Genome-Wide association studies identify OsWRKY53 as s key regulator of salt tolerance in rice”（图）
万建民 基因 分子机制 蛋白
2023/10/28
盐碱胁迫影响水稻的生长发育、存活率与最终产量。水稻耐盐碱是由多基因控制的复杂性状。研究水稻应对盐碱胁迫的关键基因及其调控网络，对于培育耐盐碱水稻品种具有重要科学意义和应用价值。2023年6月16日，国际著名期刊Nature Communications发表了万建民院士团队在水稻耐盐碱研究上的新进展。
FACILITATING PHARMACOGENETIC ASSOCIATION STUDIES USING AN EXTENSIBLE GENOTYPE INFORMATION MANAGEMENT SYSTEM
Large-scale genome Clinical Pharmacology
2015/5/27
Large-scale genome data projects employing automated, high-throughput techniques have led to a deluge of genomic data that necessitate robust informatic solutions. COBRA-DB is an integrated web-based ...
HAPPI: A Bioinformatics Database Platform Enabling Network Biology Studies
Database Genome Regulatory network
2015/5/26
The publication of the draft human genome consisting of 30,000 genes is merely the beginning of genome biology. A new way to understand the complexity and richness of molecular and cellular function o...
INTEGRATIVE SYSTEM BIOLOGY STUDIES ON HIGH THROUGHPUT GENOMICS AND PROTEOMICS DATASET
System Biology Genomics Proteomics
2015/5/26
The post genomic era has propelled us to the view that the biological systems are complex network of interacting genes, proteins and small molecules that give rise to biological form and function. The...
Effects of carbon nanotubes on airway epithelial cells and model lipid bilayers : proteomic and biophysical studies
Carbon Nanotube Calu-3 cells DPhPC lipid bilayer
2015/5/22
Carbon nanomaterials are widely produced and used in industry, medicine and scientific research. To examine the impact of exposure to nanoparticles on human health, the human airway epithelial cell li...
GENETIC STUDIES OF C-MYC ONCONGENE AND ROR1 GENE OVEREXPRESSION IN EPENDYMOMAS
C-MYC ONCONGENE GENE OVEREXPRESSION IN EPENDYMOMAS
2014/3/31
The expression of >12,000 genes in a set of 11 ependymoma samples were determined using oligonucleotide micrarrays analysis. Oncogene c-myc and gene ROR1 were identified to be highly expressed in the ...
New international research defends genome-wide association studies
genome-wide genetic variants
2014/7/17
Since 2005, genome-wide association studies (GWAS) have successfully identified thousands of genes responsible for common human diseases.
A Bayesian Method for Detecting and Characterizing Allelic Heterogeneity and Boosting Signals in Genome-Wide Association Studies
Bayesian Method Detecting Characterizing Allelic Heterogeneity Boosting Signals Genome-Wide Association Studies
2010/11/16
The standard paradigm for the analysis of genome-wide association studies involves carrying out association tests at both typed and imputed SNPs. These methods will not be optimal for detecting the si...
Application of new probabilistic graphical models in the genetic regulatory networks studies
Application probabilistic graphical models genetic regulatory networks studies
2010/11/15
This paper introduces two new probabilistic graphical models for reconstruction of genetic regulatory networks using DNA microarray data. One is an Independence Graph (IG) model with either a forward ...
Scientists have long known that DNA is arranged in a double helix. But if the double helix did not fold further, each cell's genome would be two meters long — far too large to fit into the nucleus of ...
摘要
生物钟基因普遍存在于生物界，其作用在于产生和控制昼夜节律的运转。生物钟基因及其编码的蛋白质组成反馈回路，维持振荡系统持续进行并与环境周期保持同步。各级进化水平物种生物钟的基因组成和控制途径有同有异。此文主要介绍蓝细菌、脉孢菌、果蝇、鼠和人昼夜钟的分子运作机制以及研究钟基因的意义和展望。
Abstract:The circadian clock genes,which generate ...
基因相关研究与诺贝尔奖Gene Studies and Nobel Prize
基因 诺贝尔奖 遗传学
2008/1/6
摘要基因是能够表达和产生基因产物（蛋白质或RNA）的DNA序列。到2003年为止，因为研究基因而获得诺贝尔奖的共有51人，其中获生理学或医学奖44人（占生理学或医学总获奖人数178的24.72%）、化学奖7人（占化学总获奖人数123的5.69 %）。文章从6个方面对此作了评述：果蝇是基因研究的良好材料；DNA双螺旋模型的提出为基因研究提供了坚实基础；基因调控研究阐明了基因的许多功能；遗传学中心法则...
番茄转录调控因子基因Pti5植物表达载体的构建及其转化烟草的研究Construction of a Plant Expression Vector with Tomato Transcription Factor Gene Pti5 and Studies on Transgenic Tobaccos
Pti5-VP16基因 表达载体 转化 烟草
2007/12/31
摘要本实验构建了含有CaMV35S启动子控制下的Pti5-VP16基因的植物双元表达载体pBI121UCH1。通过根癌农杆菌叶盘转化法，将Pti5-VP16基因导入烟草SRI中，经卡那霉素筛选，获得了抗性植株。经PCR和Southern印迹分析，表明抗性植株中整合了Pti5-VP16基因，经抗病性鉴定转基因烟草植株的抗病性明显提高。
Abstract:The plasmid pBI121UCH1...
云南纵坑切梢小蠹四个地理种群同工酶比较研究Comparative Studies of Isozymes in Four Geographical Populations of Tomicus piniperda L.for Yunnan Province
纵坑切梢小蠹 同工酶 等位基因频率 遗传距离 近交系数
2007/12/7
摘要采用不连续聚丙烯酰胺凝胶电泳技术研究了纵坑切梢小蠹(Tomicus piniperda L.)4个自然种群的9个同工酶基因座。4个种群均在Es-1、Es-2、Es-4、Mdh-1、Mdh-2及AAT-1基因座上存在遗传多态现象。路南长湖、楚雄、蒙自3种群间的遗传距离为0.0036～0.0173, 平均值为0.0105, 表明其遗传结构基本相似。丽江种群与上述3种群之间的遗传距离为0.1421～...
期刊信息
篇名
Studies on the interaction between analogs of distamycin and calf thymus DNA
语种
英文
撰写或编译
撰写
作者
Weihong Du,Baohuai Wang,Zhifen Li,Junhua Xiao,Gu Yuan and Weiqiang Huang
第一作者单位
刊物名称
Thermochimic...