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Synthesis of a Castasterone/Ponasterone Hybrid Compound and Evaluation of Its Molting Hormone-Like Activity
[3H]ponasterone ecdysone molting hormonal activity Chilo suppressalis insect cells
2009/3/7
Castasterone/ponasterone hybrid compound, (20R)-2α,3α,20, 22-tetrahydroxy-5α-cholestan-6-one, was newly synthesized from the corresponding α-alkoxystannane, in which the α-hydroxy group was protecte...
Synthesis of 13C-Labeled Ubiquinone-Acetogenin Hybrid Inhibitors of Mitochondrial Complex I
mitochondrial complex I acetogenin ubiquinone
2009/3/6
Natural acetogenins are the most potent inhibitors of mitochondrial complex I. By synthesizing a ubiquinone-acetogenin hybrid inhibitor (named Q-acetogenin), we previously showed that a γ-lactone ri...