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山东大学医学院医学遗传学课件（七年制） DNA polymorphisms。
Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers
MicroRNAs Gastrointestinal Neoplasms Colorectal Neoplasms Gastric Neoplasms
2015/10/13
Background: Esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (GIT) neoplasms, causing almost two million deaths worldwide each year. some environmental risk facto...
The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population
Alzheimer’s disease Genetic association Apolipoprotein E Polymorphism ATP-binding cassette transporter A1 Iran
2015/9/23
Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette t...
Interleukin-12 and Tumor Necrosis Factor-Β Gene Polymorphisms as Genetic Susceptibility Factors for Brucellosis in Iranian Patients
Brucella Genetic polymorphisms Interleukin-12 Tumor necrosis factor-β Iran
2015/9/21
cMethods: One hundred and ninety-six patients with brucellosis and 81 healthy farmers (controls) who owned infected animals and consumed their contaminated dairy products were included in this study. ...
Heme Oxigenase 2 Gene Polymorphisms as Genetic Risk Factor in Atherosclerosis in Iranian Patients
Atherosclerosis Heme oxigenase 2 Coronary artery disease Iran
2015/9/21
Background: Heme oxygenase 2 (HMOX2) is an important antioxidative stress enzyme found in the endothelial cells of blood vessels and adventitial nerves. This enzyme in collaboration with heme oxygenas...
Association between Endothelial Selectin (E-Selectin) Gene Polymorphisms and E-Selectin Level with Visceral Leishmaniais, in an ARMS-PCR Based Study
Soluble E-selectin Gene Polymorphism Visceral Leishmaniasis Human ARMS-PCR Ser128Arg 554Leu/Phe
2009/12/18
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endot...
Genetic Polymorphisms in Steroid Hormone Metabolizing Enzymes in Human Breast Cancer
Breast cancer Genetic polymorphism Steroid hormone metabolism
2009/6/26
Epidemiologic studies indicate that most risk factors for breast cancer are related to reproductive and hormonal factors. The evaluation of associations between breast cancer risk and genetic polymorp...
Common Cytochrome p4503A (CYP3A4 and CYP3A5) and Thiopurine S-Methyl Transferase (TPMT) Polymorphisms In Turkish Population
pharmacogenetics TPMT CYP3A4 CYP3A5
2009/6/22
Polymorphisms in the genes encoding cytochrome p450 (CYP) and thiopurine S-methyl transferase (TPMT) enzymes catalyze the metabolic reactions of several drugs.These polymorphisms might be responsible ...
CTLA-4 polymorphisms and anti-malarial antibodies in a hyper-endemic population of Papua New Guinea
CTLA-4 IgG IgE malaria
2010/12/10
In malaria endemic areas, people naturally acquire an age-related immunity to malaria. Part of this immunity involves anti-malarial specific antibodies. Acquisition of these malaria-specific antibodie...
山东临朐胃癌高发人群和北京人群Lewis血型抗原相关SE基因多态性分析Analysis of Polymorphisms on Lewis Blood Group Antigen Related SE Gene in the Populations in Shandong with High-risk of Gastric Cancer and Beijing
胃癌 Lewis血型抗原 SECRETOR基因 基因多态性
2007/12/30
摘要为探讨宿主的遗传背景和幽门螺杆菌（Helicobacter pylori,H.pylori）相关胃癌的易感性之间的关系，本文采用PCR产物直接测序和PCR-RFLP的方法，检测142例山东临朐县胃癌高发人群个体（包括69例癌症患者和73例非癌个体）和93例北京正常对照个体SE基因多态性的分布特点。结果显示：sew/sew基因型在山东非癌个体和北京人群之间的分布差异具有统计学意义（P＜0.01,...
No Association of Polymorphisms in the 5' Region of the CD14 Gene and Food Allergy in a Japanese Population
5' region CD14 food allergy gene polymorphism
2010/11/18
Background: The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31, a region that is linked to atopy-related phenotypes.
Although it has bee...
Association between the Polymorphisms of IL-4 Gene Promoter (-590C>T),IL-13 Coding Region (R130Q) and IL-16 Gene Promoter (-295T>C) and Allergic Asthma
Allergic asthma Interleukin-4 Interleukin-13 Interleukin-16
2010/4/2
Allergic asthma is a multifactorial disease, influenced by genetic and environmental factors. Recent family-based studies have revealed evidence for linkage of human chromosomes 5q31-33, 12q15-24, 11q...