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日前,生命学院刘木根教授团队在造血干细胞发育研究中取得重要进展。2月21日,国际血液学权威期刊Blood杂志以封面文章发表该团队研究论文“BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis”(Blood. 2019;133(8):805-81...
A team of researchers has engineered smart protein molecules that can reprogram white blood cells to ignore a self-defense signaling mechanism that cancer cells use to survive and spread in the body. ...
Biomedical engineers have grown miniature human blood vessels that exhibit many of the symptoms and drug reactions associated with Hutchinson-Gilford Progeria Syndrome—an extremely rare genetic diseas...
Researchers at the University of Illinois report they can alter blood cell development through the use of biomaterials designed to mimic characteristics of the bone marrow.The findings, reported in th...
伊利诺依大学王霏教授和他的同事李栋(生物谷专访李栋博士)等人建立了一个新的方法来研究造血干细胞向成熟白细胞分化,而后者对于机体防御外界感染或者损伤的免疫系统非常重要。这个技术为我们提供了一个新的视觉来研究髓系细胞分化的分子机制,有助于我们对于髓系细胞疾病如白血病的认识和处理。该项成果发表于10 月18 日的BLOOD上。
Background: Hematopoietic stem cell (HSC) transplantation has brought the possibility of the use of high dose chemotherapy in the treatment of malignant hematopoietic diseases. Short-term HSC preserva...
Fludarabine is an inhibitor of DNA/RNA synthesis with antitumor activity on lymphoproliferative malignancies. We investigated the dose-dependent cytotoxic effects of the drug on human peripheral blood...
Sister chromatid exchange (SCE) and chromosomal aberration (CA) in peripheral lymphocytes have been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genoto...
The findings show that intra- and extracellular properties of eosinophils can be analyzed with whole blood using PBQ fixation and OG treatment at a concentration of 7.4 mg/mL. Direct flowcytometric an...
The median concentrations of EDN in blood and urine and the number of eosinophils in peripheral blood from patients with active symptoms were all significantly higher compared with values obtained whe...
Suplatast tosilate significantly reduced TARC production by PBMCs. TARC mRNA was also suppressed in a concentration dependent manner. However, suplatast tosilate did not inhibit the expression of CCR-...
Background: Localized mast cell accumulation has been reported in a number of human diseases. Suplatast tosilate has been reported to inhibit IL-3-dependent murine mast cell development, and therefore...
To investigate the relationship between local responsiveness and allergic symptoms, bronchial and nasal responsiveness were measured in the following four groups of subjects: (i) bronchial asthma pati...

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