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The p21activated kinase 1 (PAK1) belongs to PAKs family, a group of highly evolutionarily conserved protein family of serine/threonine kinases, which acts as a downstream effector of the small GTPase...
Purification of Casein Kinase II From Lung Tissue and Kinetic Evaluations With Polyamines and Myc-Oncoprotein
Casein kinase II olyamines yc ell proliferation abbreviations KII-casein kinase II myc-phosphorylated myc oncoprotein Pmax-phosphorylated max protein
2009/7/2
The overall goal of this study was to seek molecular linkages between polyamines, casein kinase II, and the myc oncoprotein by using a cell-free, highly purified enzyme kinetic analysis. Casein kinase...
目的 探讨polo-like kinase-1（PLK1）基因对大肠癌细胞增殖和端粒酶活性的影响。 方法根据PLK1基因序列特点，设计并用化学方法合成小干扰核糖核酸分子（small interfering RNA，siRNA），转染人大肠癌SW480细胞后，分别采用实时定量PCR和Western blot检测PLK1基因mRNA和蛋白表达水平。分别采用MTT法和TRAP-ELISA方法检测PLK...
Inhibition of corneal neovascularization with new Tyrosine Kinase Inhibitors targeting vascular endothelial growth factor receptors:Sunitinib malate and Sorafenib
Cornea Sunitinib malate Sorafenib
2010/4/16
Corneal neovascularization (NV) is a significant, sight-threatening, complication of many ocular surface disorders. Presence of new vessels in cornea can compromise clarity and thus vision. The data s...
期刊信息
篇名
Role of Rho kinase and actin filament in the increased vascular permeability of skin venule in rat after scalding.
语种
英文
撰写或编译
撰写
作者
Zheng HZh,Zhao KS,Zhou BY,Huang QB
第一作者单位
刊物名称
Burns
页面
200...
Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists
β-adrenergic receptor agonist histamine release human cultured mast cells protein kinase A protein kinase C
2010/11/24
Stimulation of mast cells induced the elevation of intracellular cytosolic free Ca2+ concentrations ([Ca2+]i) and the translocation of protein kinase C (PKC) from the cytosol to the cell membrane, fol...
The effects of genistein, a tyrosine kinase inhibitor on acute and chronic inflammation in diabetic mice
Diabetes Genistein Inflammation Mice Streptozotocin Tyrosine kinase
2010/2/3
The effects of tyrosine kinases on acute and chronic inflammation during diabetes are not fully determined. Therefore, the present study focuses on the effects of genistein, a tyrosine kinase inhibito...