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SP22：a novel fertility protein from a highly conserved gene family
novel fertility protein highly conserved gene family
2009/2/17
Three nucleotide sequences encoding SP22, a protein originally identified in detergent extracts of cauda epididymal sperm, were isolated from a rat testis cDNA library. While two of these cDNA sequenc...
Seminal vesicles are novel sites of luteinizing hormone/human chorionic gonadotropin-receptor gene expression
LH/hCG receptors male accessory organs gonadotropins
2009/2/17
The hypothesis that rat seminal vesicles may contain luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors was tested by means of a number of different techniques. Northern blotting ...
Analysis of the responses of human spermatozoa to A23187 employing a novel technique for assessing the acrosome reaction
A231 87 acrosome reaction oocyte fusion human
2009/2/12
Protocols for the use of A23187 in assessing the ability of human spermatozoa to acrosome-react and exhibit sperm-oocyte fusion have been developed and the results compared in two independent cohort...
Laser oximetry：A novel noninvasive method to determine changes in penile hemodynamics in an anesthetized rabbit model
Penile erection oxyhemoglobin near-infrared spectroscopy intracavernosal pressure pelvic nerve stimulation tissue oxygen saturation
2008/12/30
This study was designed to determine the utility and validity of laser oximetry in measuring changes in penile hemodynamics. Anesthetized male New Zealand White Rabbits were divided into 2 groups, a...
Characterization of a novel transcript of 14-3-3 theta in Sertoli cells
Characterization novel transcript 14-3-3 theta Sertoli cells
2008/12/25
The isoforms of the highly conserved and ubiquitously expressed 14-3-3 family of proteins function primarily as adapters that modulate interactions between components of various cellular signaling a...
Expression and Possible Functions of a Novel Gene SPATA12 in Human Testis
Germ cell specific stage specific spermatogenesis
2008/12/24
In our previous study, a novel human testis-specific gene, SPATA12, was identified using the digital differential display program. In the current study, both SPATA12 mRNA and protein levels in...
A Novel Androgen Receptor Mutation Resulting in Complete Androgen Insensitivity Syndrome and Bilateral Leydig Cell Hyperplasia
Androgens androgen receptor gene
2008/12/24
Androgens drive male secondary sexual differentiation and maturation. Mutations in the androgen receptor (AR) gene cause a broad spectrum of abnormal phenotypes in humans, ranging from mild throu...
Biological Activity Assessment of a Novel Contraceptive Antimicrobial Agent
Hesperidin microbicides hyaluronidase STDs HIV
2008/12/23
Microbicides are a new category of compounds being developed as a prophylactic approach for the prevention of transmission of sexually transmitted diseases (STDs), including the human immunodefici...
Novel Development-Related Alternative Splices in Human Testis Identified by cDNA Microarrays
Alternative splicing spermatogenesis regulatory mechanism protein diversity spliceoforms
2008/12/23
Alternative splicing of premessenger RNA is an important regulatory mechanism that increases the diversity of proteins transcribed from a single gene. This is particularly important in the testis be...
A Suite of Novel Human Spermatozoal RNAs
Development fertility cloning microarray novel transcripts antisense RNA spermatozoa
2008/12/22
We recently described a complex population of spermatozoal coding RNAs that are delivered to the oocyte on fertilization. These are derived throughout spermatogenesis, representing a record of past ...
Molecular Cloning of Rat Spergen-3, a Spermatogenic Cell-Specific Gene-3, Encoding a Novel 75-kDa Protein Bearing EF-Hand Motifs
Spermatogenesis spermiogenesis spermatid calcium-binding protein differential display
2008/12/22
By use of differential display in combination with cDNA cloning approach, we isolated a novel rat gene designated as Spergen-3, which has an open reading frame of 2055-length nucleotides encoding ...
Expression of a Novel RAD23B mRNA Splice Variant in the Human Testis
RAD23 alternative splice ubiquitin spermatogenesis proteolysis self-balance
2008/12/22
A gene coding a novel human RAD23B protein named RAD23-like protein B, presumably involved in spermatogenesis, was identified and characterized using a complementary DNA (cDNA) microarray. In the hu...
The Use of Novel Semen Quality Scores to Predict Pregnancy in Couples With Male-Factor Infertility Undergoing Intrauterine Insemination
Overall semen quality relative quality semen pregnancy score outcome prediction
2008/12/19
The purpose of this study was to determine whether 2 new semen quality (SQ) scores could predict pregnancy in patients undergoing intrauterine insemination (IUI) for male-factor infertility and whet...
Inhibition of Tonic Contraction—A Novel Way to Approach Erectile Dysfunction?
Inhibition Tonic Contraction Erectile Dysfunction
2008/12/15
Experiments from this laboratory have demonstrated that vasoconstriction in the cavernosal circulation is mediated, in part, by the RhoA/Rho-kinase calcium-sensitization pathway. When RhoA/Rho-kinase ...
Prostate Epithelial Expression of a Novel Androgen Target Gene
Hpg up-regulation subtractive hybridization differential expression in situ hybridization
2008/12/8
To better understand the role of androgens in prostate development and disease it is important to characterize androgen-regulated genes in the prostate. Using suppression subtractive hybridization...