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Androgen regulation of the human ornithine decarboxylase promoter in prostate cancer cells
Androgen receptor gene regulation
2009/2/17
We studied the response of the human ornithine decarboxylase (ODC) promoter to androgen in human prostate cancer cell lines. In the well-differentiated, androgen-sensitive human prostate cancer li...
Biphasic Effect of Androgens on Prostate Cancer Cells and Its Correlation With Androgen Receptor Coactivator Dopa Decarboxylase
Neuroendocrine differentiation methyltoenolone cDNA microarray
2008/12/24
The aim of this study was to explore the mechanism underlying the dual effect of androgen on prostate cancer cells and further explore its correlation with dopa decarboxylase (DDC), an androgen r...
Androgens Induce Increases in Intracellular Calcium Via a G Protein–Coupled Receptor in LNCaP Prostate Cancer Cells
5-Dihydrostestosterone Ca2+ GPCR
2008/12/24
The receptor mechanism of testosterone-induced nongenomic Ca2+ signaling in prostate cancer cells is poorly understood. In this study we investigated androgen-induced intracellular Ca2+ increa...
Gene Expression in Prostate Cancer Cells Treated With the Dual 5 Alpha-Reductase Inhibitor Dutasteride
LNCaP gene-expression profiling REDUCE trial apoptosis
2008/12/22
We sought preclinical data on the cellular and molecular effects of dutasteride in androgen-responsive, human prostate cancer (PCa) cells to better understand the mechanisms of action of 5 alpha-red...