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Intraventricular gabapentin is antinociceptive and enhances systemic morphine antinociception in rat tail flick test
Intraventricular Gabapentin Tail- flick
2010/4/26
Background: Gabapentin has been recently considered as an analgesic in neurpathic pain through spinal site of action. In addition co-administration of low dose of morphine with gabapentin, is proposed...
PROTECTIVE EFFECT OF VITAMIN D3 IN METHYLPREDNISOLONE ACETATE (MPA) INDUCED LOSS OF BONE METABOLISM MARKERS AND BONE MINERAL DENSITY IN THE LUMBAR SPINE OF RAT
Methylprednisolone acetate vitamin D3 bone markers metabolism
2010/4/7
Although some vitamins have been shown to prevent glucocorticoids induced osteoporosis in short time, the magnitude of this effect remains to be clarified. The aim of this study was to evaluate protec...
Spasmolytic effect of Vitis vinifera leaf extract on rat colon
Vitis vinifera Antispasmodic Colon
2010/4/7
Vitis vinifera (grape) leaf has been used traditionally to treat diarrhea and its extract induces relaxation in rat aorta and uterus. The aim of present study was to investigate the effect of grape le...
Simultaneous determination of metoprolol, propranolol and phenol red in samples from rat in situ intestinal perfusion studies
Propranolol Metoprolol Phenol red liquid chromatography Permeability
2010/2/3
Single-pass intestinal perfusion technique (SPIP) is the most used classic technique employed in the study of intestinal absorption of compounds in which a non-absorbable marker such as phenol red is ...