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THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/28
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ANTAGONIST, GW9662, ALTERS UVB-INDUCED INFLAMMATORY RESPONSES, APOPTOSIS, AND DELAYED HYPERPROLIFERATION
PPARγ UVB COX-2
2015/1/19
It has recently been shown that the gamma subtype of the peroxisome proliferator-activated receptor (PPARγ) is a target of ultraviolet B (290-320 nm; UVB) irradiation, and that PPARγ activation is nec...
Transcriptional Expression Profile of Toll Like Receptor 1 - 10 mRNA in Bovine Peripheral Mononuclear Cells in Response to Foot and Mouth Disease Antigens
Innate Immunity FMDV DNA Vaccine TLR Genes
2013/1/28
Toll like receptors are the primary component of innate immune response. The comparison of expression of innate immune genes TLR 1 - 10 was carried out by real time PCR by quantifying mRNA in bovine P...
Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNF
TrkB Alzheimer BACE1 SHC NFAT
2013/1/28
Brain derived neurotrophic factor (BDNF) levels and signaling via the tyrosine receptor kinase B (TrkB) have been shown to be altered in Alzheimer’s Disease. In addition, it has been reported that the...
5-HT2A Receptor Activation Normalizes Exaggerated Fear Behavior in p-Chlorophenylalanine (PCPA)-Treated Rats
Fear Conditioning Startle Reflex 5-HT2 DOI Ketanserin SB 206553
2013/1/29
Deficits in serotonin (5-hydroxytryptamine, 5-HT) neurotransmission are implicated in abnormal emotional behaviors such as aggression, anxiety, and depression. However, the specific 5-HT receptor mech...
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis
Chemokine Receptor CCR9 Rheumatoid Arthritis
2013/1/31
Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone ...
Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis
Chemokine Receptor CCR9 Rheumatoid Arthritis Inflammation Antigen-Induced Arthritis Mouse Mod-el Monocytes/Macrophages
2013/9/2
Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone ...
Expression of short-chain fatty acid receptor GPR41 in the human colon
short-chain fatty GPR41
2009/12/16
Short-chain fatty acids (SCFAs), including acetate, propionate and butyrate, are the most commonly found anions found in the monogastric mammalian large intestine, and are known to have a variety of p...
Effects of a dopamine receptor agonist and atropine sulfate on absorption of valproic acid in rats
dopamine receptor absorption valproic acid rats
2009/5/8
The aim of this study is to determine whether pramipexole hydrochloride hydrate (PHH) and atropine sulfate affect valproic acid (VPA) pharmacokinetics and to evaluate how plasma VPA concentrations a...
Sensitive Indirect Spectrophotometric Method for Determination of H2-Receptor Antagonists in Pharmaceutical Formulations
H2-receptors antagonists cerium (IV) p-dimethylaminocinnamaldehyde spectrophotometry pharmaceutical analysis
2009/4/20
A simple, accurate and sensitive spectrophotometric method has been developed and validated for determination of H2-receptor antagonists: cimetidine, famotidine, nizatidine, and ranitidine hydrochlori...
Medial Expression of TNF-α and TNF Receptors Precedes the Development of Atherosclerotic Lesions in Apolipoprotein E/LDL Receptor Double Knockout Mice
atherosclerosis lipoproteins TNF-α TNF receptors
2009/4/20
TNF-α is present in atherosclerotic lesions, activates endothelial adhesion molecule expression, stimulates the release of proinflammatory cytokines and matrix metalloproteinases and promotes smooth ...
Expression of Retinoic Acid Receptor (RAR) α Protein in the Synovial Membrane from Patients with Osteoarthritis and Rheumatoid Arthritis
osteoarthritis rheumatoid arthritis retinoic acid receptor synovial membrane
2009/4/20
Retinoic acid receptors (RAR) are expressed in inflammatory cells and, through ligand binding, play an important role in cell proliferation and differentiation, as well as in regulation of cytokine an...
An Angiotensin II (Ang II) Type 1 Receptor Blocker, Telmisartan, Improves Insulin Resistance in KK-Ay Diabetic Mice
telmisartan insulin resistance hypertension diabetes PPAR-γ
2009/4/20
Metabolic syndrome is strongly associated with insulin resistance and consists of a constellation of factors such as hypertension and hyperlipidemia that raise the risk for cardiovascular diseases and...
Identification of copper-binding nuclear proteins in mouse brain: its involvement in retinoic acid receptor signaling
copper-binding nuclear proteins mouse brain retinoic acid receptor signaling
2009/4/1
Copper is an essential micronutrient with numerous cellular functions. Previous studies have demonstrated that copper deficiency in P19 embryonal carcinoma cells by using a copper depletor, bathocupro...
Organotin-Induced Toxicity and Nuclear Receptor Signaling
organotin aromatase endocrine disruptor retinoid X receptor (RXR) peroxisome proliferator-activated receptor (PPAR) γ
2009/3/23
Organotin compounds have been widely used as agricultural fungicides, rodent repellents, and molluscicides and in antifouling paints for ships and fishing nets. These widespread uses have resulted in ...