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清华大学江鹏课题组在《美国科学院院报》（PNAS）发表了题为“p53缺陷通过诱导MTHFD2转录上调促进细胞增殖和抑制DNA损伤”的研究论文。本项研究揭示了p53缺失或突变肿瘤细胞对一碳代谢酶MTHFD2的极端依赖性。
Is Stat3 and/or p53 mRNA expression a prognostic marker for renal cell carcinoma?
Stat3 p53 mRNA cell carcinoma
2009/12/16
Signal transducer and activator of transcription (Stat) 3 and p53 integrate upstream signals, and are positive and negative regulators of tumor cell proliferation, respectively. Stat3 and p53 also neg...