搜索结果: 1-15 共查到“知识库 理学 mass spectrometry”相关记录76条 . 查询时间(0.078 秒)
Colocalization of the Ganglioside GM1 and Cholesterol Detected by Secondary Ion Mass Spectrometry
Cholesterol G(M1) Ganglioside Lipid Bilayers Spectrometry, Mass, Secondary Ion Molecular Conformation Biological Transport Microtechnology Nanotechnology Models, Molecular
2016/5/25
The characterization of the lateral organization of components in biological membranes and the evolution of this arrangement in response to external triggers remain a major challenge. The concept of l...
Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples
membrane organization chemical composition imaging NanoSIMS ToF-SIMS dynamic SIMS
2016/5/25
Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sens...
Phase Separation of Lipid Membranes Analyzed with High-Resolution Secondary Ion Mass Spectrometry
Cell Membrane Membrane Microdomains Membrane Lipids Lipid Bilayers Phosphatidylcholines Membrane Proteins Spectrometry, Mass, Secondary Ion Nanotechnology
2016/5/24
Lateral variations in membrane composition are postulated to play a central role in many cellular events, but it has been difficult to probe membrane composition and organization on length scales of t...
Supported Membrane Composition Analysis by Secondary Ion Mass Spectrometry with High Lateral Resolution
cryosolvents sugar glass glycerol water trytophan indole IR flourescence phosphorescence
2016/5/24
The lateral organization of lipid components within membranes is usually investigated with fluorescence microscopy, which, though highly sensitive, introduces bulky fluorophores that might alter the b...
Simultaneous determination of 58 major and trace elements in volcanic glass shards from the INTAV sample mount using femtosecond laser ablation-inductively coupled plasma-mass spectrometry
volcanic glass tephra LA-ICP-MS element abundance femtosecond lasert
2017/4/10
Four volcanic glass samples on the INternational focus group on Tephrochronology And Volcanism (INTAV) sample
mount described by Kuehn et al. (2011) were analyzed to establish a new methodology for m...
Origin of unusual fractionation of Pb isotope ratios with calcium in thalliumspiked multiple collector-inductively coupled plasma mass spectrometry
Pb isotope, fractionation, MC-ICPMS
2017/4/10
We report the origin of significant fractionation of Pb isotope ratios in Ca-doped 0.08 mol L–1 HNO3 solutions. We
applied Tl-spiked standard bracketing mass fractionation correction using solution-b...
Determination of relative Faraday cup efficiency factor using exponential law mass fractionation model for multiple collector thermal ionization mass spectrometry
Faraday cup efficiency TIMS Sr isotope exponential
2017/4/10
A new method for determining the relative Faraday cup efficiency (RFCE) for nine Faraday cups has been developed
using 86Sr, 87Sr, and 88Sr isotope signals, and the exponential mass fractionation law...
Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.
Chemical cross-linking/mass spectrometry targeting acidic residues proteins protein complexes.
2015/12/11
The study of proteins and protein complexes using chemical cross-linking followed by the MS identification of the cross-linked peptides has found increasingly widespread use in recent years. Thus far,...
Development and Application of a Mass Spectrometry-Based Quantitative Assay for Apolipoprotein M in Human and Mouse Serum
Mass Spectrometry Cholesterol Apolipoprotein M MS-Based Assay
2015/5/26
Apolipoprotein M (apoM) is necessary for the formation of lipid-poor preβ-HDL particles, the initial precursor of HDL and acceptors of cholesterol efflux from peripheral cells. An assay to quantify ap...
Analysis of Histone Lysine Methylation Using Mass Spectrometry
MudPIT histones transcription
2015/5/25
Histones are highly basic proteins which when digested by trypsin are hard to analyze using mass spectrometry. Because histones are basic nuclear proteins, a nuclei prep followed by acid extraction is...
Retinoic Acid Transfer And Protein-Protein Interaction Between The Cellular Retinoic Acid Binding Protein And The Retinoic Acid Receptor Probed By Hydrogen Deuterium Exchange Mass Spectrometry
Pure sciences Cellular retinoic acid binding proteins Hydrogen deuterium exchange Protein-protein interactions Retinoic acid receptors Retinoic acid
2014/12/11
Retinoic acid (RA) is the most potent metabolite of vitamin A and is utilized in signaling pathways that control many cellular events. Cellular retinoic acid binding proteins I and II are carriers of ...
MASS SPECTROMETRY BASED EXPERIMENTAL STRATEGIES TO CHARACTERIZE NATIVE AND NON-NATIVE DISULFIDE BONDS IN CYSTEINE-RICH PROTEIN THERAPEUTICS
Mass spectrometry disulfide scrambling protein therapeutics disulfide-bond characterization
2014/12/10
The impact post-translational modifications (PTMs) can have on the structure, function, and immunogenicity of protein therapeutics makes it especially important for these protein-based treatments to b...
Enhanced Detection Strategies Accomplished Through Metal Binding and Miniature Mass Spectrometry
Metal binding Miniaturization Multiplexed MS/MS
2014/11/20
A multiplexed method for performing MS/MS on multiple ions simultaneously in a miniature rectilinear ion trap (RIT) mass spectrometer has been developed. This method uses an ion encoding procedure tha...
Development of Mass Spectrometry-Based Methods for Quantitation and Characterization of Protein Drugs: Transferrin as a Model Drug Delivery Vehicle
Mass Spectrometry O18 labeling Protein quantitation Transferrin
2014/11/20
In the last two decades, protein drugs have enjoyed a rapid growth and achieved a tremendous success in treating human diseases. However, the presence of physiological barriers greatly impedes the eff...
Microanalysis of Pb isotope ratios of low-Pb glass samples by femtosecond laser ablation-multiple ion counter-ICP-mass spectrometry (fsLA-MIC-ICP-MS)
Pb isotopes laser ablation ICP-MS multiple ion counting (MIC) silicate glass geological reference materials
2017/4/11
We report high-resolution in situ Pb isotope analysis (207Pb/206Pb and 208Pb/206Pb ratios) by femtosecond laser
ablation-multiple ion counter-inductively coupled plasma-mass spectrometry (fsLA-MIC-IC...