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近日，山西医科大学山西省出生缺陷和细胞再生重点实验室解军教授团队在 《Cell Death & Disease》杂志发表了最新研究成果“Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects”。
Why might the finding of a new genetic association with inflammatory bowel disease be of potential value in disease control?
new genetic association inflammatory bowel disease potential value disease control
2018/11/20
Inflammatory bowel disease (IBD) has long been recognized as an exaggerated inflammatory response to common antigenic stimuli in the gut. Ulcerative colitis (UC) (1) and Crohn disease (CD) (2) are the...
Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults
cardiometabolic risk cerebrovascular disease choline older adults magnetic resonance imaging nutrition
2018/11/14
Background: There is a potential role of choline in cardiovascular and cerebrovascular disease through its involvement in lipid and one-carbon metabolism.
2017 “健康和疾病翻译机”高登研究研讨会（The Gordon Research Seminar on Translation Machinery in Health and Disease）
Health Disease
2017/3/8
The Gordon Research Seminar on Translation Machinery in Health and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education t...
The role of gluten consumption at an early age in celiac disease development: a further analysis of the prospective PreventCD cohort study
celiac disease children gluten HLA European cohort
2018/11/13
Background: We previously found that the introduction of small quantities of gluten at 4–6 mo of age did not reduce the risk of celiac disease (CD) in a group of high-risk children. However, the consu...
Association of dietary cholesterol and egg intakes with the risk of incident dementia or Alzheimer disease: the Kuopio Ischaemic Heart Disease Risk Factor Study
Alzheimer disease apolipoprotein E4 cholesterol cognitive function,
2018/11/12
Background: There is little information about the associations of intakes of cholesterol and eggs, a major source of dietary cholesterol, with the risk of cognitive decline in general populations or i...
Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction
obesity liver steatosis insulin resistance intestinal permeability gut barrier
2018/11/12
Background: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier.
Objective: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with...
Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease
biomarker coronary artery disease inflammation mortality vitamin B-6
2018/11/30
Background: Low vitamin B-6 status has been related to increased risk of coronary artery disease (CAD), which is a condition that is associated with inflammation. The most common status marker, plasma...
Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease
COPD arginine citrulline nitric oxide protein breakdown
2018/11/30
Background: Chronic obstructive pulmonary disease (COPD) is a condition characterized by systemic low-grade inflammation that could increase the production of nitric oxide (NO), of which arginine is t...
Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level
fatty liver gene expression liver injury metabolomics transaminases
2018/11/27
Background: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental cha...
Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Parkinson’s Disease Genes VPS35 EIF4G1 Interact Genetically Converge on α-Synuclein
2015/12/11
Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein.
The role of the Borrelia oxidative stress regulator protein in virulence gene expression of the Lyme disease spirochete
Borrelia burgdorferi, BosR RpoS
2015/5/21
The Lyme disease agent, Borrelia burgdorferi, has a complex system that allows it to thrive in the harsh and distinct environments of its tick vector and mammalian host. Although it has been known for...
An IL-4-dependent macrophage-iNKT cell circuit resolves sterile inflammation and is defective in mice with chronic granulomatous disease
macrophage-iNKT cel chronic granulomatous disease
2015/5/21
The immune system initiates tissue repair following injury. In response to sterile tissue injury, neutrophils infiltrate the tissue to remove tissue debris and subsequently undergo apoptosis. Proper c...
The regulation of allergic airway disease by type V collagen-induced tolerance
IL-17 Type V Collagen
2015/5/21
Tissue remodeling and complement activation are asthma hallmarks. Type V collagen [col(V)], a cryptic antigen, becomes exposed during lung remodeling. IL-17 is key to anti-col(V) immunity, and regulat...
Human Niemann-Pick Type C2 Disease Protein Expression, Purification and Crystallization
Niemann-Pick type C2 NPC2 Structure Expression Crystallization Purification
2014/12/12
Niemann-Pick type C2 (NPC2) protein is a soluble protein that binds unesterified cholesterol. The protein helps transport unesterified cholesterol in tandem with the membrane protein Niemann-Pick type...