搜索结果: 1-9 共查到“知识库 儿科学 CELL”相关记录9条 . 查询时间(0.14 秒)
Repression of cyclin D1 as a target for germ cell tumors
metastatic germ cell tumors cyclin D1
2014/12/12
Metastatic germ cell tumors (GCT) are curable, however GCTs refractory to cisplatin-based chemotherapy have a poor prognosis. This study explores D-type cyclins as molecular targets in GCTs because al...
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
DNA repair gene therapy
2014/12/12
Reactive oxygen species (ROS) have been implicated as one of the agents responsible for many neurodegenerative diseases. A critical target for ROS is DNA. Most oxidative stress-induced DNA damage in t...
Knockdown of the DNA repair and redox signaling protein Ape1/ Ref-1 blocks ovarian cancer cell and tumor growth
base excision repair APE1/Ref-1 ovarian cancer
2014/12/12
Apurinic endonuclease 1/redox effector factor-1 (Ape1/Ref-1 or Ape1) is an essential protein with two distinct functions. It is a DNA repair enzyme in the base excision repair (BER) pathway and a redu...
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
Rac Cdc42
2014/12/12
Critical to homeostasis of blood cell production by hematopoietic stem/progenitor (HSC/P) cells is the regulation of HSC/P retention within the bone marrow microenvironment and migration between the b...
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics
mast cells Pak1 allergic diseasis
2014/12/12
Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators. The biochemical pathways linking IgE...
An 18-year Follow-up of Allergy Development Related to Nasal Metachromatic Cell Findings During Infancy
allergy cohort study metachromatic cells nasal epithelium prediction
2010/11/12
The cumulative number of subjects with allergy was 46, probable allergy 5, and no allergy 13. Detected MCinfancy predicted allergy with high accuracy (31/33), but negative MCinfancy findings did not e...
Identification of Hitherto Undefined B-Cell Epitopes by Antibodies in the Sera of Vitiligo Patients Using Phage-Display Peptide Library
B-cell Epitope Random Peptide Library Self-antigen
2010/4/22
A random 12 mers phage library was used to screen a pool of immunoglo¬bulin fractions obtained from vitiligo patients. Subsequent to panning experiments, a panel of affinity selected phage from vi...
B-cell Lineage Study in Patients with Juvenile Idiopathic Arthritis
B-cell Lineage Immunophenotyping Juvenile idiopathic arthritis Chronic Arthritis
2009/12/17
Objective: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. The exact causes of disease are still poorly understood. It seems that B cells have several functions i...
Short Term Reactogenicity of a Triple Diphtheria-Tetanus-Whole Cell Pertussis Vaccine in Iranian Infants
Diphtheria-Tetanus-Pertussis Vaccine Vaccination Reactogenicity Infant Local reaction Systemic reaction Iran
2009/12/14
Background: Immunization against diphtheria, tetanus and pertussis (DTP) has long been applied in Iran using whole cell vaccine. Despite the role of whole cell DTP (DTwP) vaccine in reduction of ...