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In genetical genomics studies, it is important to jointly analyze gene expression data and genetic variants in exploring their associations with complex traits, where the dimensionality of gene expres...
In genetical genomics studies, it is important to jointly analyze gene expression data and genetic variants in exploring their associations with complex traits, where the dimensionality of gene expres...
High-throughput sequencing technologies are currently revolutionizing the field of biology and medicine, yet bioinformatic challenges in analysing very large data sets have slowed the adoption o...
With the rapid increase in production of genetic data from new sequencing technologies, a myriad of new ways to study genomic patterns in nonmodel organisms are currently possible. Because genome as...
In 1944, Oswald Avery, Colin MacLeod, and Maclyn McCarty demonstrated that DNA was the chemical basis of heredity and the genetic cornerstone of life on Earth (Avery et al., 1944). Some 30 years later...
The post genomic era has propelled us to the view that the biological systems are complex network of interacting genes, proteins and small molecules that give rise to biological form and function. The...
Toxic spills, hypoxia, disease outbreaks and toxin-producing algal blooms are all possible causes of mass mortality events, but in many cases it can be difficult to pinpoint the cause of death...
Across heterogeneous landscapes, populations may have adaptive differences in gene regulation that adjust their physiologies to match local environments. Such differences could have origins in acclim...
摘要 苔藓植物具有相对简单的发育模式,单倍体的配子体在其生活史中占主导地位,作为研究植物生物学过程的模式系统具有诸多的优越性。苔藓植物小立碗藓能够高效地通过同源重组的方式将外源核酸整合到其核DNA,这就使得基因打靶在此物种中就像在小鼠胚胎干细胞和酵母中一样成为一个非常便利的技术。另外由于小立碗藓与高等植物在生物特征上有很大相似之处加之其有其他诸多优越性,它有望成为一个诱人的植物生物学和功能基因组...
随着人类基因组计划(Human Genome Project)以及哺乳动物基因组计划 (Mammalian Genome Project)的展开,大规模的基因组测序及拼接排序工作 都已经接近尾声,我们已经进入一个后基因组时代(Post-Genomic Era)。这些 计划的完成不但为生命科学研究提供了新的思路、策略和技术方法,而且促进了 其他学科,特别是生物医药、化学、信息科学的发展。随着...

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