搜索结果: 1-15 共查到“知识库 医学 DHA”相关记录28条 . 查询时间(0.026 秒)
观察DHA对七氟烷诱导的小胶质细胞TLR4/MyD88/NFκB信号通路激活及炎症介质释放的影响。方法： N9小鼠小胶质细胞分为Con组、Sevo组和DHA+Sevo组，药物处理各组细胞24h后，采用MTT方法检测小胶质细胞存活率，采用western blot方法检测小胶质细胞TLR4、MyD88和IκB-α的表达量，检测各组培养基中炎症介质TNF-α、IL-1β和IL-6的含量。
DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/14
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
Prenatal supplementation with DHA improves attention at 5 y of age: a randomized controlled trial
attention child development fatty acids prenatal supplementation omega-3 fatty acids preschool cognitive development
2018/12/18
Background: Docosahexanoic acid (DHA) is an important constituent of the brain. Evidence from well-designed intervention trials of the long-term benefits of increasing DHA intake during pregnancy has ...
A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study
DHA EPA inflammation men and women randomized controlled trial risk factors
2018/12/13
Background: To date, most studies on the anti-inflammatory effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in humans have used a mixture of the 2 fatty acids in various forms and...
Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight
birth weight DHA FADS long-chain PUFAs prenatal supplementation
2018/11/29
Background: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsatu...
Long-term effect of high-dose supplementation with DHA on visual function at school age in children born at <33 wk gestational age: results from a follow-up of a randomized controlled trial
docosahexaenoic acid DHA preterm infant very preterm visual processing
2018/11/26
Background: Children born preterm are at risk of visual-processing impairments. Several lines of evidence have contributed to the rationale that docosahexaenoic acid (DHA) supplementation of preterm i...
DHA- Rich Fish Oil Improves Complex Reaction Time in Female Elite Soccer Players
Fatty acids omega 3 efficiency decision-making
2015/5/7
Omega-3 fatty acids (n-3) has shown to improve neuromotor function. This study examined the effects of docosahexaenoic acid (DHA) on complex reaction time, precision and efficiency, in female elite so...
DHA对人肝癌细胞增殖与凋亡的影响及其机制的研究
癌 肝细胞 二十二碳六烯酸类 细胞凋亡
2014/5/11
探讨二十二碳六烯酸（DHA）对人肝癌细胞株Bel-7402增殖和凋亡的影响及其机制。方法：用不同浓度的DHA（0，25，50，100，200 μmol/L）分别作用人肝癌Bel-7402细胞24，48，72 h后，用MTT法检测细胞的增殖情况、Western blot检测Bcl-2和Bax蛋白的表达，并分别用流式细胞仪、real-time PCR和caspase-3活性检测试剂盒检测上述梯度浓度的...
初步探讨败血症患儿血标本分离的人苍白杆菌耐药机制。方法采用VITEK2 compact全自动微生物鉴定药敏系统对败血症患儿分离的病原菌进行鉴定和药敏试验；聚合酶链反应（PCR）法对人苍白杆菌受试株进行AmpC、AmpR、DHA1、AcrA、RamA、OprD、TEM、SHV等多重耐药基因检测，扩增产物经纯化后测序并进行序列分析。结果从败血症患儿的血标本中检出155株人苍白杆菌，从中随机选取30株...
DHA对脂多糖致小鼠急性肺损伤保护作用
二十二碳六烯酸 内毒素 急性肺损伤 氧化应激
2014/8/6
观察二十二碳六烯酸(DHA)预防脂多糖(LPS)性小鼠急性肺损伤(ALI)的效果,探讨其抗氧化作用机制。方法 雄性昆明种小鼠经灌胃给予DHA 250、500 mg/kg,连续10 d,然后经腹腔注射6 mg/kg脂多糖建立ALI模型;染毒16 h后,分别对各组动物肺组织进行病理学观察,支气管-肺泡灌洗液(BALF)和肺脏中氧化、抗氧化指标检测。结果 脂多糖明显损伤肺组织氧化和抗氧化系统,DHA能明...
DHA对老年大鼠嗅球神经因子和载脂蛋白影响
二十二碳六烯酸 神经营养因子 载脂蛋白E 载脂蛋白J
2014/7/28
探讨二十二碳六烯酸(DHA)对老年大鼠嗅球中神经生长因子(NGF)和脑源性神经营养因子(BD-NF)和载脂蛋白E(APOE)和J(APOJ)的影响。方法 分别用180、360 mg/kg DHA灌胃24月龄老年大鼠49 d,处死大鼠取嗅球,用酶联免疫吸附试验(ELISA)测定脑组织NGF、BDNF含量,用western blotting测定载脂蛋白E和J的表达量。结果 180、360 mg/kg ...
DHA介导GPR40转染PC12细胞内的钙离子动员。
富含EPA或DHA海洋微藻胶囊开发技术
微藻胶囊 海洋药物
2008/12/16
1.课题来源及背景：高度不饱和脂肪酸(pUFA)，尤其是N-3系列的廿碳五烯酸(epA)和廿二碳六烯酸(DHA)具有很强的生理活性，是人和动物生长、发育所必需的脂肪酸。它们具有抗血栓、防止血小板聚结、舒张血管、降低胆固醇和甘油三酯等作用。海洋微藻是海洋中的初级生产力，具有合成epA、DHA的奇特能力，鱼和其他海洋动物自身不能合成epA和DHA，它们是通过食物链(即海洋微藻→浮游动物→鱼及其他的海洋...