搜索结果: 1-12 共查到“知识库 基础医学 Alzheimer”相关记录12条 . 查询时间(0.14 秒)
THERAPEUTIC IMPLICATIONS OF COMPUTER MODELS OF BRAIN ACTIVITY FOR ALZHEIMER DISEASE
COMPUTER MODELS
2015/7/31
Neural models of large-scale brain processes help to explain many features of neuropsychological syndromes and psychiatric disease. Two associative memory models useful to understand some aspects of c...
Novel regulation of neuronal genes implicated in Alzheimer disease by microRNA
Alzheimer APP BACE1 microRNA post-transcriptional gene regulation amyloid fetal neurons
2015/5/21
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β peptide (Aβ) as neuritic plaques in the brain. The short Aβ peptide is derived from a large transmembrane precurs...
EVALUATION OF GENE REGULATION AND THERAPEUTIC DRUGS RELATED TO ALZHEIMER’S DISEASE IN DEGENERATING PRIMARY CEREBROCORTICAL CULTURES
Alzheimer synapse neurodegeneration primary culture memantine
2015/5/21
Alzheimer’s disease (AD) is a neurological disorder defined by the presence of plaques comprised mostly of amyloid-β (Aβ), and neurofibrillary tangles consisting of hyperphosphorylated microtubule ass...
MRI Measures of Neurodegeneration as Biomarkers of Alzheimer's Disease
magnetic resonance imaging (MRI) Alzheimer's disease (AD) mild cognitive impairment (MCI) biomarkers cognitive complaints Alzheimer's Disease Neuroimaging Initiative (ADNI) visual contrast sensitivity
2015/5/21
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disease. Many researchers believe that an effective AD treatment will prevent the development of disease rather than treat the...
Depressive Symptom Endorsement among Alzheimer’s Disease, Vascular Dementia and Mild Cognitive Impairment
Depression Cognitive Impairment Alzheimer’s Vascular Dementia Mild Cognitive Impairment
2013/8/30
Background: The Geriatric Depression Scale (GDS) is widely used to assess depressive symptoms in clinical and research settings. This study utilized a 4 factor solution for the 30-item GDS to explore ...
Depressive Symptom Endorsement among Alzheimer’s Disease, Vascular Dementia and Mild Cognitive Impairment
Depression Cognitive Impairment Alzheimer’s Vascular Dementia Mild Cognitive Impairment
2013/1/31
Background: The Geriatric Depression Scale (GDS) is widely used to assess depressive symptoms in clinical and research settings. This study utilized a 4 factor solution for the 30-item GDS to explore ...
The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population
Alzheimer’s disease Genetic association Apolipoprotein E Polymorphism ATP-binding cassette transporter A1 Iran
2015/9/23
Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette t...
Antioxidant Status,Lipid Peroxidation Products and Cystatin C as Potential Clinical Markers of Alzheimer's Disease in Systemic Circulation
Alzheimer's disease serum oxidative stress marker Cystatin C
2009/6/29
Growing data suggest oxidative stress contributes to the pathogenesis of Alzheimer's disease (AD). The objective of this study was to assess the value of antioxidant potential (AOP), antioxidant statu...
组织蛋白酶D基因C224T多态与散发阿尔茨海默氏病的关联研究The C224T Polymorphism in the Cathepsin D Gene is not Associated with Sporadic Alzheimer’s Disease in Chinese
阿尔兹海默氏病 组织蛋白酶基因 多态性 限制性片段长度
2008/1/10
摘要
组织蛋白酶D（Cathepsin D）是一种细胞核内体/溶酶体内的门冬酰胺蛋白酶。它有可能通过剪切淀粉样前体蛋白参与阿尔茨海默氏病（Alzheimer’s disease, AD）相关的神经退化。在以德国人为对象中的研究显示组织蛋白酶D基因（CTSD）C224T多态与AD发病风险紧密相关。然而，此结果未能在另一些群体中得到重复。为此，我们通过聚合酶链反应-限制性片段长度多态性方法分析了C...
摘要阿尔茨海默类痴呆（AD）是老年痴呆中最常见的一种,它以渐进性的神经功能退化并伴随着整体认知能力的下降为特征。早发性AD主要是由β-淀粉样前体蛋白（APP）基因和早老素基因突变引起，而与晚发性AD发病明显相关的只有载脂蛋白E-ε4 ( APOE-ε4)等位基因。但是APOE-ε4等位基因对AD发病既非充分又非必要，而且只能解释少于50%的AD的遗传变异。所以有必要进一步寻找与AD的关联基因。
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Alzheimer病患者MLL3基因表达量的研究
Alzheimer病 MLL3基因 表达量 关联
2007/12/19
目的 本工作旨在从MLL3(mixed-lineage leukemia 3, MLL3)基因入手，尝试探讨Alzheimer病（Alzheimer’s disease，AD）与该基因表达量的相关关系。 方法 工作在45例AD患者、25例血管性痴呆(vascular dementia，VD)患者和60名年龄性别相匹配的对照中进行，在新鲜外周血样本中抽提总RNA，反转录成cDNA，基因表达量的检测在...
NEUROPATHOLOGICAL CHANGES IN THE PDAPP TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE
Alzheimer's disease immunohistochemistry medal septal nucleus diagonal band of Broca
2010/2/3
Alzheimer’s disease (AD) is a uniquely human disorder. Although the pathogenesis of AD is not fully understood, growing evidence indicates that the deposition of beta-amyloid (Aβ) and the local reacti...