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EFFECTS OF CHOLINE KINASE ACTIVITY ON PHOSPHOLIPID METABOLISM AND MALIGNANT PHENOTYPE OF PROSTATE CANCER CELLS
hypoxia cancer HIF
2015/5/25
High choline uptake and increased choline kinase activity have been reported in many cancers. This has motivated the use of choline as a biomarker for tumor imaging. Tumors in general are heterogeneou...
An inhibitor of the mitotic kinase, MPS1, is selective towards pancreatic cancer cells
CIN70 MPS1 kinase inhibitor pancreatic cancer
2015/5/21
The abysmal five year pancreatic cancer survival rate of less than 6% highlights the need for new treatments for this deadly malignancy. Cytotoxic drugs normally target rapidly dividing cancer cells b...
Metastatic breast cancer and circulating tumour cells
Metastatic breast cancer circulating tumour cells
2015/4/14
Circulating tumour cells – often referred to as a ‘liquid biopsy’ for cancer – can be found in a large proportion of patients with breast cancer that has spread to other organs. Changes in circulating...
Disparate functions of myeloid-derived suppressor cells in cancer metastasis
Disparate functions cancer metastasis
2015/4/14
Myeloid-derived suppressor cells comprise a heterogeneous population of immature immune cells that expand during the course of cancer progression. These cells adopt an immunosuppressive phenotype that...
CD4+ T cell mediated tumor immunity following transplantation of TRP-1 TCR gene modified hematopoietic stem cells
Melanocyte Differentiation Antigen Lentiviral Vectors
2015/5/21
Immunotherapy for cancer has held much promise as a potent modality of cancer treatment. The ability to selectively destroy diseased cells and leave healthy cells unharmed has been the goal of cancer ...
SYNERGISTIC ANTITUMOR EFFECT OF ASCORBIC ACID,LYSINE,PROLINE,AND EPIGALLOCATECHIN GALLATE ON HUMAN FIBROSARCOMA CELLS HT-1080
Antitumor activity ascorbic acid cell proliferation cytotoxicity EGCG fibrosarcoma lysine Matrigel invasion matrix metalloproteinases MMP MMP-2 MMP-9 MMP-inhibitors MTT assay nutrient synergy proline toxicity
2009/7/15
Introduction: Matrix metalloproteinases (MMPs) have received much attention in recent years for their role in various malignancies, and have been implicated in tumor invasion, metastasis and angiogene...
APPLICATION OF GENETICALLY ENGINEERED TUMOR-SPECIFIC TH1 CELLS TO ADOPTIVE TUMOR IMMUNOTHERAPY
Carcinoembryonic antigen chimeric immunoglobulin T cell receptor DO11.10 gene transfer immunotherapy
2009/7/15
CD4+ Th cells, in particular IFN-γ-producing Th1 cells, play a critical role in the activation and maintenance of CD8+ Tc1 cells that are essential for tumor eradication. Recent identification of MHC ...
Specific Antitumor Effects of Tumor Vaccine Produced by Electrofusion between Osteosarcoma Cell Line and Dendritic Cells in Rats
Dendritic cell osteosarcoma tumor vaccine
2009/7/15
Background: Dendritic cells (DCs) are the strongest antigen presenting cells (APCs). They can present antigen to T lymphocytes in vivo and in vitro, and induce cytotoxic T lymphocyte (CTL) reactions. ...
Synergy Effect of Vitamin K3 on Cytotoxicity of Campthotecin in HCT116 Cells
Synergy vitamin K3 menadione camptothecin
2009/7/15
Vitamin K is a fat-soluble vitamin involved in clotting factors of blood coagulation system. Recently, various studies about bone metabolism and anti-cancer effect in vitamin K have been reported. The...
Sensitivity to CPT-11 and platinum derivatives of stage II/III node-positive gastric cancer with occult neoplastic cells in lymph node sinuses
Gastric cancer occult neoplastic cells CPT-11 Topoisomelase-1 inhibitor platinum agents Bax ERCC-1 isolated tumor cells
2009/7/15
In this study, immunohistochemistry was used to detect Topo-1 and Bax/ERCC-1 expression in patients who had lymph node metastasis of stage II/III gastric cancer with occult neoplastic cells (ONCs) in ...
Individual CDR3 Regions as Targets for Detection of Clonal Cells in Acute Lymphocytic Leukemia
Minimal residual disease Acute lymphocytic leukemia CDR3
2009/6/26
Immunoglobulin heavy chain rearrangements provide a specific identity of complementarity determining region 3 (CDR3) DNA sequences. For this reason, CDR3 regions may be used in the diagnosis of malign...
Cytotoxicity of Low Dose Epirubicin-HCI Combined with Lymphokine Activated Killer Cells Against Hepatocellular Carcinoma Cell Line Hepatoma G2
Hepatoma epirubicin-HCI cytotoxicity enzymes
2009/6/23
Recent evidance supports the concept that Epirubicin-HCI and Lymphokine-activated killer cells (LAK) cytotoxicity may be mediated by free radical and oxyradical generation. We tested this hypothesis f...