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浙江大学生命科学研究院2022年5月2日徐平龙实验室在Nature Cell Biology发文鉴定首条非经典cGAS-STING通路及其控制蛋白质合成和器官纤维化病变的关键功能（图）
徐平龙 非经典cGAS-STING通路 蛋白质合成 器官纤维化病变
2022/10/25
2022年5月2日，浙江大学生命科学研究院徐平龙实验室在Nature Cell Biology上在线发表了题为“A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis”的研究长文，鉴定了一条物种进化上非常古老的cG...
Effects of interstitial fluid flow and cell compression in FAK and SRC activities in chondrocytes
FAK Src Mechanotransduction
2015/1/12
Articular cartilage is subjected to dynamic mechanical loading during normal daily activities. This complex mechanical loading, including cell deformation and interstitial fluid flow, affects chondroc...
THE ROLE OF DAP-KINASE IN MODULATING VASCULAR ENDOTHELIAL CELL FUNCTION UNDER FLUID SHEAR STRESS
DAP-K Mechano-transduction Apoptosis Shear Atherosclerosis
2015/1/12
Atherosclerosis preferentially develops in vascular regions of low or disturbed flow and high spatial gradients. Endothelial cells that line the vessel walls actively participate in translating mechan...
Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties
Raloxifene mechanicaltesting toughness water
2014/11/6
Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties,...
Anaplastic Large Cell Lymphoma, ALK-Negative Presenting in the Rectum: A Case Report and Review of the Literature
Anaplastic Large Cell Lymphoma CD30+ Lymphoma
2013/1/31
ALK-negative anaplastic large cell lymphoma (ALCL, ALK－) is a CD30+ T-cell neoplasm composed of large lymphoid cells with abundant cytoplasm and pleomorphic nuclei that lacks expression of ALK protein...
Salivary and Serum IgA Evaluation of Patients with Oro-Facial Squamous Cell Carcinoma
Saliva Serum Immunoglobulin Oro-Facial Squamous Cell Carcinoma
2013/1/29
Objective: To evaluate salivary and serum levels of Immunoglobulin A (IgA) in patients with oro-facial squamous cell carcinoma. Methods: This is a cross sectional study. Patients with oro-facial squam...
Aged Garlic Extract Reduces ROS Production and Cell Death Induced by 6-Hydroxydopamine through Activation of the Nrf2-ARE Pathway in SH-SY5Y Cells
Aged Garlic Extract (AGE) 6-OHDA ROS Nrf2-ARE Pathway SH-SY5Y Cells
2013/2/19
Many degenerative or pathological processes, such as aging, cancer and coronary heart disease, are related to reactive oxygen species (ROS) and radical-mediated reactions. We examined the effectivenes...
In Vitro Characterization of Docetaxel as a Radiosensitizer in Canine and Feline Cancer Cell Lines
Docetaxel Chemotherapy Radiation Therapy In Vitro
2013/2/19
An In Vitro study was conducted to investigate docetaxel as a radiation sensitizer in four canine (mammary carcinoma—CMT12 and CMT25, osteosarcoma—OS2.4, and transitional cell carcinoma—PTCC), and one...
Canine Cutaneous Mast Cell Tumor: Biologic Behavior and Its Correlation with Prognostic Indicators
Sabrina dos Santos Costa Poggiani Erika Maria Terra
2013/2/19
Cutaneous mast cell tumor (MCT) shows a variable biological behavior in dogs and may present either as solitary masse that can be treated and cured with surgical removal or as a systemic metastatic an...
Evaluation of Collection and Distribution of Samples for Histological, Stereological Analysis and Cell Culture of Canine Mast Cell Tumors
Mast Cell Tumor Oncologic Surgery Canine Tumor Collection Stereological Analysis
2013/2/19
Objective: To collect high quality, representative tissue material from tumors and manage its distribution to different laboratories. Design: Prospective controlled study. Animals: Thirty-six dogs wit...
Current status of Radiologic Diagnosis for Mediastinal Lymph Node Metastases of Non-Small-Cell Lung Cancer: Retrospective Study of pN2 Cases
Non-Small-Cell Lung Cancer Mediastinal Lymph Node Metastasis
2013/2/19
Objective: Advances in diagnostic imaging techniques, such as 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), have led to greater accuracy in preoperative mediastinal staging for patien...
A phase I study with Satraplatin and simultaneous chest radiation for non-small cell lung cancer
Non-Small Cell Lung Cancer Chemoradiation Satraplatin Phase I Study Toxicity
2013/1/29
Introduction: Satraplatin has been given in combination therapy for lung cancer to utilize its radio-sensitizing properties. The optimal dose of satra-platin given concurrently with radiation therapy ...
Adverse Effects of Morphine and Fentanyl for Stomatitis in Patients Receiving Allogeneic Hematopoietic Cell Transplantation—A Single Center Retrospective Analysis
Stomatitis Morphine Fentanyl Allo-HCT Constipation
2013/1/30
Opioids are widely used as analgesics for oral mucositis in allogeneic hematopoietic cell transplantation (allo-HCT). Their main adverse events are nausea, vomiting, constipation, psychological sympto...
Inhibition of the Renin Angiotensin System during Autologous Stem Cell Transplant Does Not Impact Time to Engraftment
Multiple Myeloma ACE Inhibitor Angiotensin Receptor Blocker Melphalan Neutropenia
2013/1/30
Background: The renin angiotensin system RAS modulates hematopoiesis via local effects in the bone marrow. Angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) may ...
Use of Continuous Regional Anesthetic for Management of Pediatric Sickle Cell Crisis
Sickle Cell Crisis Regional Anesthesia Pediatric Pain
2013/1/30
Sickle cell patients often find difficulty obtaining adequate treatment of pain. Anti-inflammatory medications, steroids, and opioids can reduce pain; however their use is limited by side effects. We ...